The problem is that the screen reader can't be easily routed to channels 3 and 4. You'll need to implement a workaround if the APO equalizer isn't working.
Whatever you want to do, you need to route the screen reader to channels 3 and 4. The easiest way was to copy the channels in APO, but if that doesn't work, you'll need to find an alternative method, such as Reaper with the "App 2 Clap" and "Clap 2 App" plugins.
If you can't route the screen reader to channels 3 and 4, you can use two audio cards, for example, the master = controller and the headphones = computer.
Best regards, Zenek