Otto Warburg Nobel Prize Winner 1931 The prime Cause of Cancer June 30 1966

[Dr Stephen M Gibson ND]

Otto Heinrich Warburg was born on October 8, 1883, in Freiburg, Baden.
His father, the physicist Emil Warburg, was President of the
Physikalische Reichsanstalt, Wirklicher Geheimer Oberregierungsrat.
Otto studied chemistry under the great Emil Fischer, and gained the
degree, Doctor of Chemistry (Berlin), in 1906. He then studied under
von Krehl and obtained the degree, Doctor of Medicine (Heidelberg), in
1911. He served in the Prussian Horse Guards during World War I. In
1918 he was appointed Professor at the Kaiser Wilhelm Institute for
Biology, Berlin-Dahlem. Since 1931 he is Director of the Kaiser
Wilhelm Institute for Cell Physiology, there, a donation of the
Rockefeller Foundation to the Kaiser Wilhelm Gesellschaft, founded the
previous year.


http://www.nobelprize.org/nobel_prizes/medicine/laureates/1931/warburg-bio.html




The Prime Cause and Prevention of Disease
http://www.ionizers.org/Otto-Warburg.html

Dr. Otto Warburg's Address to Nobel Laureates,
June 30, 1966 at Lindau, Lake Constance, Germany

O. Warburg won the Nobel Prize in Medicine in 1931 for his discovery
of the oxygen transferring enzyme of cell respiration

Editor's Note:


- What follows below is even more interesting when tied in to what
Dr. Hidemitsu Hayashi, M.D. Director, Water Institute of Japan, has
stated:

"When taken internally, the effects of reduced water are immediate.
Ionized Water inhibits excessive fermentation in the digestive tract
by reducing indirectly metabolites such as hydrogen sulfide, ammonia,
histamines, indoles, phenols and scatoles, resulting in a cleaner
stool within days after reduced water is taken on a regular basis."

In 1965, just before Dr. Otto made the following speech the Ministry
of Welfare of Japan announced that reduced water obtained from
electrolysis can prevent abnormal fermentation of intestinal
microbes.



Cause and Prevention of Disease

There are prime and secondary causes of diseases. For example, the
prime cause of the plague is the plague bacillus, but secondary causes
of the plague are filth, rats, and the fleas that transfer the plague
bacillus from rats to man. By the prime cause of a disease, I mean one
that is found in every case of the disease.

Cancer, above all other diseases, has countless secondary causes.
Almost anything can cause cancer. But, even for cancer, there is only
one prime cause. The prime cause of cancer is the replacement of the
respiration of oxygen ... in normal body cells by fermentation of
sugar.

All normal body cells meet their energy needs by respiration of
oxygen, whereas cancer cells meet their energy needs in great part by
fermentation. All normal body cells are thus obligate aerobes, whereas
all cancer cells are partial anaerobes. From the standpoint of the
physics and chemistry of life this difference between normal and
cancer cells is so great that one can scarcely picture a greater
difference. Oxygen gas, the donor of energy in plants and animals, is
dethroned in the cancer cells and replaced by the energy yielding
reaction of the lowest living forms, namely the fermentation of
sugar.

In every case, during the cancer development, the oxygen respiration
always falls, fermentation appears, and the highly differentiated
cells are transformed into fermenting anaerobes, which have lost all
their body functions and retain only the now useless property of
growth and replication. Thus, when respiration disappears, life does
not disappear, but the meaning of life disappears, and what remains
are growing machines that destroy the body in which they grow.

To prevent cancer it is therefore proposed first to keep the speed of
the blood stream so high that the venous blood still contains
sufficient oxygen; second, to keep high the concentration of
hemoglobin in the blood; third, to add always to the food, even of
healthy people, the active groups of the respiratory enzymes; and to
increase the doses of these groups, if a precancerous state has
already developed. If at the same time exogenous carcinogens are
excluded rigorously, then much of the endogenous cancer may be
prevented today.

These proposals are in no way utopian. On the contrary, they may be
realized by everybody, everywhere, at any hour. Unlike the prevention
of many other diseases, the prevention of cancer requires no
government help, and not much money.

Many experts agree that one could prevent about 80% of all cancers in
man, if one could keep away the known carcinogens from the normal body
cells. But how can the remaining 20%, the so-called spontaneous
cancers, be prevented? It is indisputable that all cancer could be
prevented if the respiration of body cells were kept intact.

Nobody today can say that one does not know what the prime cause of
cancer is. On the contrary, there is no disease whose prime cause is
better known, so that today ignorance is no longer an excuse for
avoiding measures for prevention. That the prevention of cancer will
come there is no doubt. But how long prevention will be avoided
depends on how long the prophets of agnosticism will succeed in
inhibiting the application of scientific knowledge in the cancer
field. In the meantime, millions of men and women must die of cancer
unnecessarily."

--------------------------------------------------------------------------------

Excerpts from Follow-Up Lecture by Otto Warburg, Director, Max Planck-
Institute for Cell Physiology, Berlin-Dahlem
English Edition by Dean Burk, National Cancer Institute, Bethesda,
Maryland, USA

If a lowered oxygen pressure during cell growth may cause cancer, or,
more generally, if any inhibition of respiration during growth may
cause cancer, then a next problem is to show why reduced respiration
induces cancer. Since we already know that with a lowering of
respiration fermentation results, we can re-express our question: Why
does cancer result if oxygen-respiration is replaced by fermentation?

The early history of life on our planet indicates that life existed on
earth before the earth's atmosphere contained free oxygen gas.
The living cells must therefore have been fermenting cells then, and,
as fossils show, they were undifferentiated single cells.
Only when free oxygen appeared in the atmosphere - some billion years
ago - did the higher development of life set in, to produce the plant
and animal kingdoms from the fermenting, undifferentiated single
cells.

The reverse process, the dedifferentiation of life, takes place today
in greatest amount before our eyes in cancer development, which is
another expression for dedifferentiation. To be sure, cancer
development takes place even in the presence of free oxygen gas in the
atmosphere, but this oxygen may not penetrate in sufficient quantity
into the growing body cells, or the respiratory apo-enzymes of the
growing body cells may not be saturated with the active groups. In any
case, during the cancer development the oxygen - respiration always
falls, fermentation appears, and the highly differentiated cells are
transformed to fermenting anaerobes, which have lost all their body
functions and retain only the now useless property of growth. Thus,
when respiration disappears, life does not disappear, but the meaning
of life disappears, and what remains are growing machines that destroy
the body in which they grow.

But why oxygen differentiates and why lack of oxygen dedifferentiates?
Nobody would dispute that the development of plants and animals and
man from unicellular anaerobes is the most improbable process of all
processes in the world... But according to the thermodynamics of
Boltzmann, improbable processes require work to take place. It
requires work to produce temperature differences in a uniformly
temperatured gas; whereas the equalization of such temperature
differences is a spontaneous process that does not require work. It is
the oxygen - respiration that provides in life this work, and
dedifferentiation begins at once when respiration is inhibited in any
way. In the language of thermodynamics, differentiation represents a
forced steady state, whereas dedifferentiation - that is, cancer - is
the true equilibrium state. Or, illustrated by a picture: the
differentiated body cell is like a ball on an inclined plane, which,
would roll down except for the work of oxygen-respiration always
preventing this. If oxygen respiration is inhibited, the ball rolls
down the plane to the level of dedifferentiation.
In Summary:Impairment of respiration is more frequent than impairment
of fermentation because respiration is more complicated than
fermentation.
The impaired respiration can be easily replaced by fermentation,
because both processes have a common catalyst, the nicotinamide.
The consequence of the replacement of respiration by fermentation is
mostly glycolysis, with death of the cells by lack of energy. Only if
the energy of fermentation is equivalent to the lost energy of
respiration, is the consequence anaerobiosis. Glycolysis means death
by fermentation, anaerobiosis means life by fermentation.
Cancer arises, because respiration, but not fermentation, can maintain
and create the high differentiation of body cells.

The physicist MANFRED VON ARDENNE ... recently discovered that cancer
cells owing to their fermentation, are more acid - inside and on their
surface - than normal cells ...

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