Take a look at the community wiki:
http://www.tiddlywiki.org/wiki/Launching_Programs
> The next steps would be to integrate the graphic into the layout and
> to make it interactive. I'll check for this later.
You'd likely require some side of server-side component to serve the
image file ready for inclusion.
As for interactivity, you might use HTML image maps.
Have you seen these projects:
http://www.tiddlywiki.org/wiki/Visualization
-- F.