Shorts, saddles, and crotch issues are very individual and variable. Whatever I'm going to say here is based on my own body type, riding style, and experience coaching and fitting hundreds of triathletes and cyclists. That does not necessarily mean it will apply to you, but my advice will be different from the typical randonneur and ultracyclist in this group.
I'm going to respond from a different perspective: an ultradistance triathlete specializing in races like Ironman (30+), Ultraman (2.5 times Ironman distance) who also did solo RAAM, 12-36 hour races, and rodecomparable or higher training miles to most randonneurs preparing for PBP. I probably averaged over 260+ miles/week for Ironman training and maybe 500 miles/week for RAAM. I don't attempt this distance any more due to aging and a lot of reasons, but NOT due to saddle sores. These miles were 80-90% in the aero position, and I was one of the best time-trial/triathlon aero bike fitters in the world (trained by John Cobb, who pretty much invented the science with Greg Lemond and Lance Armstrong), and I frequently had the top bike split in my age group in Ironmans, and won a national championship in the time for 50+ in 2011. I also coached hundreds of triathletes and cyclists mostly in the Ironman (180km bike) and longer distances, including a female world champion in Kona. I won the 6- and 12-hour races at the Texas Time Trials several times.
That being said, I did have problems with saddle sores but never race- or ride-ending ones. Usually I had the kind that were really an aggravated pimple, but these could become abscessed, as did one on my testicle that had to be surgically drained by a urologist. I'm going to agree with most previous responses that the cause is probably NOT primarily the riding shorts (but these do have a big effect), but rather the riding position.
The first thing to remember is that your riding position, power output and stress on your crotch will change over time. I put out about 170 watts FTP for one hour now compared to 330 watts at my peak at age 51. That means a lot more weight on the saddle every pedal stroke, because your legs are not lifting your pelvis up as much. My aero position has also become much conservative with time, though I still ride in aero position 50% of the time in the Texas wind, just higher up and on a more conservative endurance bike, not my time-trial/racing bike all the time like I did 15 years ago. Hence the change in saddles.
As a friend and student of John Cobb and a dealer of his Cobb saddles, I was on those a long time, even after he sold his company. I rode for a number of years on his Delta P saddle (which was called the Plus 2 when I rode it), both for time trials, triathlons, and all the randonneuring brevets, both on my ultradistance bike in aero and on my faster time trial bike in the aero position. This worked well for about age 47-59 (before that, just standard San Marco tri saddle with padded nose, not a split saddle). I did have saddle sores occasionally, depending on the season, and the worst times were spring and fall, when the bike volume was high, but temperatures will still low enough for sweat not to evaporate. Swimming more in the summer in chlorinated water (a disinfectant), and riding in high heat up to 110F, made my sweat have so much salt content and evaporate quickly enough that the bacteria that causes saddle sores did not grow as much. Winter was also relatively sore-free, due to cold temperatures, low sweat rates, and reduced volumes.
About five years ago, as bike power and volume decreased, I started to get more saddle sores in specific areas due to the split V-shaped Cobb saddle. I was putting out less power, sitting up more often, and therefore putting more pressure on that spot between testicle and thigh. Aero position tends to distribute about 10-20% more weight forward, and reduced power also increased the rear weight. My body weight stayed about the same: I'm a big, power rider (185 pounds), like Cancellara in his best days, but could still climb and run well enough. I looked more like a football linebacker or fullback than an endurance athlete. Now I still weigh the same, but with a lot less muscle mass and strength, hence less power and speed.
So switched to the Adamo ISM 3.1 saddle around 2018-19, which has a small u-shaped cutout, but not the sharply sloping v-shaped padded cut out of the Cobb saddle. This flatter, more rounded split saddle eliminated the pressure points and the area-specific sores (ride in crease between testicle and thigh). They still augmented riding in aero position, but also worked well for long periods of only sitting up position, which happened sometimes for six months straight after two shoulder surgeries and heart surgery in the past two years. I've only been able to ride in aero again for the last two months. You won't see any randonneurs with these, but you'll see them everywhere at Ironman. If you know the history of aero positioning and saddles like I do, you'll know that John Cobb originally designed THAT saddle as well, but broke off from that partner and started his own. Some of his employees went with Adamo as well. Nowadays, the two saddles don't look as much alike anymore. Adamo and ISM also have seemed to split now, so that performance saddles are now just ISM at:
https://ismseat.com/performance-narrow/pn-3-1/
Constant politics and business shifts with saddles: Butts and crotches are big business, if you did not already know :-)
Now about the crotch specifically and sports lubricants. I know there's been a lot of talked about not using cycling creme at all, going completely dry, or using things like baby powder only. This has been popular at times, especially in the days of leather cycling pads (which I used to love) and hard leather saddles. I don't think it's optimal with modern pads and saddles, though. The technology has just come too far now to ignore. I have tried every kind of crotch lube, including the expensive Assos Chamois Creme (a pro cyclist favorite), which I used for about ten years all the time, and still do occasionally. It is usually best spread on the saddle itself, not the crotch. But I don't use it as much anymore, even though it feels great, especially at first. I does not have sufficient antibacterial to prevent the kind of sores (and possible infections) that I can get.
So I went back to an old favorite, Sports Slick, which I'd used for decades for both cycling as a general lubricant for marathons on Ironmans on my chest, around arm pits for wetsuits, etc. It DOES have excellent antibacterial properties. It's also hard to get, only through the manufacturer now. I can't find it from amazon or other dealers any more. It's rather expensive but worth it to me. My wife uses it, too. I have at times, during bad saddle sore periods, used BOTH the chamois creme on the bike short pad AND sports slick on my crotch. Slippery, but helpful when desperate. It might work for you since you are desperate and a friction-related problem. If I were your coach, I'd recommend trying that combination first.
http://www.sportslick.com/The last five years I've been happy with the Adamo saddle and the sports slick. That being said, due to changes in age, racing and lifestyle, I don't do 300km+ rides anymore and did my last FULL Ironman in 2022, mostly due to marathon running issues. Right now, I'm training for 30-mile hikes in high altitude in Tibet at 15-18,000 feet in May 2025. So is my wife. I am back up to 4-6 hour long rides after shoulder surgery, and still seem relatively fast compared to LSR folks, but definitely not like a was in my competitive racing days. I still do half-marathon and may do half-Ironman again.
I have always loved the Pearl Izumi top of the line shorts, both bib and short, for over 25 years--the pad has changed a lot over that time, for the better in general. I have also used Sugoi a lot because that's the house brand for Ironman logo shorts, which I have a lot of. And of course, I've ridden a lot with tri shorts and skin suits with minimal pad. These are not as comfortable on the bike, but have never caused saddle sores anymore than regular bike shorts. Other sponsor's shorts I have tried, but never purchases of my own volition. Generally speaking the more expensive brands like Assos and Pearl Izumi are better, but sometimes there second-tier model is also good for shorter rides.
Of course, this email was too long, but try the sports slick and ISM saddle and see. Whatever you do, only buy bike components with a 30-day trial period with full return privileges, which I always do. I've probably returnedover $25,000 worth of gear for a refund in my career. You don't know until you ride it for a 100 miles or more.
Regards,
Tom Rodgers