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![]() RESEARCH Blood Test Aims to Detect Autism ![]() To cut through some of the mystery of mental disorders, universities and medical-technology companies are seeking firmer biological clues that may be lurking in blood and saliva--so-called biomarkers. The 20-site, 660-patient project, expected to be launched Wednesday, is thought to be one of the biggest studies to date to examine a biological marker for autism-spectrum disorders, which affect one in every 50 children in the U.S. The blood test aims to speed the diagnosis of autism, a condition characterized by poor social interaction and repetitive behaviors that can be hard to recognize when a child is very young. The average age of diagnosis in the U.S. is about 4 years, older than is optimal, according to experts, because therapies are more effective when begun early. "Time is the enemy here in improving outcomes," said Stan Lapidus, chief executive of SynapDx, a lab-services company in Lexington, Mass., that is sponsoring the trial. SynapDx, which is backed by venture-capital firms and is paying for the trial, has no ties to any autism treatment but hopes to make money by selling the test if it is commercialized. A challenge with developing a detection or diagnostic test is to accurately identify those with a condition while keeping the false positives to a minimum. Currently, there is no objective test for autism, and it is diagnosed based on an examination of the child's behavior by experts. The blood test could augment pediatricians' and parents' observations and help them make the decision to get the child to a specialist sooner, but not replace the clinician's diagnosis. For
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Vol.
17 No. 5
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