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![]() RESEARCH No Evidence Multiple Vaccines Raise Autism Risk, CDC Says 'Too Many Vaccines Too Soon' Not a Valid Concern Medscape Medical News ![]() (Photo: Toby Talbot,
AP)
The number of childhood vaccines administered, either in a single day or during the first 2 years of life, has no bearing on autism risk, new research from the Centers for Disease Control and Prevention (CDC) shows. The case-control study of more than 1000 children showed that there were no significant differences between those who did and those who did not have an autism spectrum disorder (ASD) in total antigens from vaccines received by age 2 years or in the maximum number of antigens received on a single day. In addition, increasing exposure to antibody-stimulating proteins or polysaccharides from vaccines from the age of 3 months to 2 years was not associated with risk of developing an ASD. "Our study found no relationship with the number of vaccine antigens received and overall ASD, autistic disorder, or ASD with regression," lead author Frank DeStefano, MD, MPH, director of the Immunization Safety Office at the CDC in Atlanta, Georgia, told Medscape Medical News. The investigators noted in a release that although the current routine schedule contains more childhood vaccines than were administered a couple decades ago, "the maximum number of antigens that a child could be exposed to by 2 years of age in 2013 is 315, compared with several thousand in the late 1990s." "Because different types of vaccines contain varying amounts of antigens, this research acknowledged that merely counting the number of vaccines received does not adequately account for how different vaccines and vaccine combinations stimulate the immune system," they add. The study was published online March 29 in the Journal of Pediatrics. Lingering Concerns According to the investigators, almost one third of parents express concern that vaccines may cause autism, and nearly 1 in 10 parents therefore refuse or delay vaccinations recommended by the CDC. Initial concerns stemmed from a now-disputed study by Andrew Wakefield that linked autism to the measles, mumps, and rubella vaccine. Numerous follow-up studies by other research groups and a 2004 review by the Institute of Medicine have led to the rejection of Wakefield's suggestion of possible causal associations. In addition, a 3-part series of articles and editorials in the BMJ in 2011, as reported at the time by Medscape Medical News, charged that Wakefield's study was "an elaborate fraud." Nevertheless, concerns persist — especially regarding the question of whether infants and children are receiving too many vaccines too soon, report the investigators. The investigators evaluated combined data from 3 managed care organizations for 256 children with an ASD and 752 age- and sex-matched healthy For
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Vol.
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