limitations for MQM with BC1F5?

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Robert Bowden

Feb 17, 2021, 8:40:43 PMFeb 17
to R/qtl discussion
Hi All, 
In the MQM Tutorial (2014), it says: 
"The current implementation of R/qtl-MQM has the following limitations: (1) MQM is limited to experimental crosses F2, BC, and selfed RIL "  We have been using MQM on BC1F5 using BC.gen=1 and F.gen=5. It seems to work really great, but seems to contradict the Tutorial. Are we doing something bad? Hoping that limitation got updated.

Danny Arends

Feb 18, 2021, 5:56:47 AMFeb 18
to R/qtl discussion
As long as the marker ratios are not too far off a normal BC population (25 : 75), it should be fine to use MQM
The limitations were write like this is prevent people from trying things like 4-way crosses

Kind regards,

Robert Bowden

Feb 18, 2021, 10:21:23 AMFeb 18
to R/qtl discussion
Thanks for the fast response!  Yes, our ratios are right on 25:75 except for two loci with segregation distortion due to selection for winter phenotype in our winter wheat x spring wheat cross. We are very impressed with Rqtl and especially MQM. Thanks for all your work on it!
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