Just recently, installed PyScripter 3.0 & Python 3.6 64bit editions in Windows 10 Pro 64bit Fall Creators' Update and performed a file write to user/appdata/local and everything worked out of the box. PyScripter functioned properly, the python module was saved correctly, and edit with PyScripter context menu option worked correctly from within the local appdata directory. Just an FYI and use case test for anyone interested.
PyScripter works with the absolute newest versions of Python and Windows 10 64bit Editions; enjoy!