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什么是乳腺癌的内分泌治疗
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daoyu...@gmail.com
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Jan 26, 2007, 2:09:15 AM
1/26/07
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早在1896年Beatson首次报告了患转移性乳腺癌的中年妇女,在切除卵巢之后病情得到缓解。Lett于1905年报道了99例实施双侧卵巢切除治疗晚期乳腺癌,有效率达41.3%,其中客观有效率为36.4%,同时绝经后病人用卵巢切除术方法治疗无效,从而确认有些乳腺癌的生长与内分泌有关。在应用内分泌治疗后,可使有些肿瘤细胞的分裂得到抑制,生长缓慢,使肿瘤的发展得到缓解。近20多年来,由于广泛开展了雌激素受体测定,能够帮助选择应用内分泌治疗的指征。内分泌治疗的作用机制与化疗不同,内分泌治疗主要是抑制癌细胞的分裂,其作用速度较化疗慢,获得部分或全部缓解常需要数周或数月。如果应用内分泌治疗有效的病人,其缓解程度、生存的质量均较应用化疗的病例疗效为好。
内分泌治疗包括去除内分泌腺体的治疗及内分泌药物的治疗。
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