The big difference is the lack of high speed data support for the
Desire. Seems they left out 3G compatibility for the US. That really
blows. Other than that i dont see much of a difference. I am like you
though Chad, Im waiting for the unlocked Nexus One and I'm activating
it on US Cellular if possible.
Here is a link to a much more detailed comparison
http://www.slashgear.com/htc-desire-vs-google-nexus-one-2074966/