Hi Inge,
We are no longer developing the “classic” GenMAPP program, and the
databases that are available are out of date. It is quite possible
that the problems you are seeing are due to outdated databases. I
would recommend switching to one of our other tools instead.
We are currently developing GenMAPP-CS (
http://www.genmapp.org/beta/
genmappcs/) which is still in beta, but is available for use. This
program will eventually replace the classic GenMAPP.
If you prefer to work with non-beta software, I would highly recommend
PathVisio (
www.pathvisio.org), which performs the same functions as
the classic GenMAPP (and more). If you are already familiar with
GenMAPP, this program will be easy to use since it was modeled after
GenMAPP. The databases available for PathVisio are up-to-date and more
extensive.
While PathVisio can perform over-representation analysis on pathways,
I would also recommend using GO-Elite (
http://www.genmapp.org/
go_elite/) for over-representation on pathways and GO terms. This
program was developed in our lab, and is also incorporated into
GenMAPP-CS. You can use either a standalone application or run it
through a web interface.
Hope this helps.
Regards,
Kristina
Kristina Hanspers, ME
GenMAPP-CS Development Team
Bioinformatics Research Associate/Conklin Lab
Gladstone Institute of Cardiovascular Disease/UCSF
http://www.genmapp.org/beta/genmappcs/