I'm completely new to DynamoRIO... I downloaded 8.0.0-1 and ran the sample as suggested in
How to Run (dynamorio.org). Specifically, I ran "c:\DynamoRIO-Windows-8.0.0-1\bin64>drrun.exe -c C:\DynamoRIO-Windows-8.0.0-1\samples\bin64\bbsize.dll -- notepad" on my up to date x64 Win10 box. Notepad launches just fine and when I exit it, I get the sample client bbsize notice with the number of basic blocks and such. But when I run Notepad and click on the File->Open... menu item, it churns for a while before prematurely popping up the sample client bbsize notice. While the Notepad window is still open at that point, it's frozen. The moment I click OK, the Notepad process is terminated/exits.