Systems Biology Theory lunch seminar: Towards knowledge-based semantic integration of models

[zuc...@research.dfci.harvard.edu]

folks

Thought you might be interested...
http://vcp.med.harvard.edu/tl-schedule.html
see you there.

best,

j.

12 Oct 2007

Carolyn Talcott
Computer Science Lab
SRI International
Abstract

In spite of standards efforts such as SMBL and BioPax it remains difficult
to share models of biological processes (for example signal transduction
or metabilism). It is even more difficult to combine models of similar
processes developed by different researchers not to mention models of
different processes/aspects, to obtain a bigger picture.

I will present some preliminary thoughts on a possible approach to
improving the situation based on an attempt to represent the biological
knowledge underlying the models in a framework that is (hopefully)
independent of specific analysis tools (MatLab, PRISM ...) but that
supports reasoning about the knowledge.

I will also discuss some of the specific issues that arose in a modest
case study of models of signaling due to EGF stimulation. I will also
mention similar issues that arise when importing models from publicly
avaialable data bases.

Hopefully this will elicit discussion of additional issues that must be
faced and lead to some productive brainstorming about how to make progress
in practice.