Parasite Plague is a growing concern for healthcare professionals
Pastor Dale Morgan
Parasite Plague is a growing concern for healthcare professionals*
One in 3,800 donors in the L.A. area tested positive for Chagas, a
deadly disease that is mainly found in Latin America.
By Rong-Gong Lin II, Times Staff Writer
March 15, 2007
A little-known but potentially deadly parasite from Latin America has
become one of the latest threats to the blood and organ supplies in the
United States, especially in Los Angeles, where many donors have
traveled to affected countries, health officials say.
Last year, two heart transplant patients at different Los Angeles
hospitals contracted the parasitic disease, called Chagas, causing
health authorities to issue a national bulletin. Within months, both
patients subsequently died, although not directly from Chagas, according
to the U.S. Centers for Disease Control and Prevention.
The parasite, which is generally passed to humans from a blood-sucking
insect that looks like a striped cockroach, can feed over years on
tissues of the heart and gastrointestinal tract. After decades, tissues
can be eroded so much that the organs fail.
Insect transmission of the parasite in the United States is rare, but
public health and blood bank officials have been concerned about its
increasing prevalence in the blood supply.
In 1996, using an experimental test, the American Red Cross found that
one in 9,850 blood donors in the L.A. area tested positive for the
parasite, Trypanosoma cruzi. Two years later, it was one in every 5,400.
By 2006, a more refined test detected the parasite in one in 3,800
donors. About 10% to 30% of infected people develop symptoms of chronic
disease, experts say.
By contrast, HIV, which blood banks screen for, shows up in one of every
30,000 donors, said Susan Stramer, executive scientific officer for the
Red Cross.
If caught early, strong anti-protozoal drugs such as nifurtimox can
bring the parasite to undetectable levels or, in some cases, eliminate
it entirely.
If the parasite is given the chance to multiply over years or decades,
however, those infected may have to be treated with heart-regulating
drugs or get a pacemaker or heart transplant.
The U.S. Food and Drug Administration approved a test suitable for
widespread screening in December. Blood banks have now begun
systematically checking their supplies for the Chagas parasite.
By late January, the American Red Cross and Phoenix-based Blood Systems,
which collect about 65% of the U.S. blood supply, had started screening
blood for T. cruzi. Other banks, including the Blood Bank of San
Bernardino and Riverside Counties, have no immediate plans for screening
but are monitoring test results from banks that are using the test. In
late February, the CDC reported that the "FDA is expected to recommend
implementation of the test by all blood-collection establishments."
No organ donors in the United States are now being screened for the
parasite, although the organ procurement agency that covers much of
Southern California plans to begin testing some donors in mid-April. At
first, the screening will be focused on people who have lived in or
traveled to rural parts of Latin America, said Thomas Mone, chief
executive of the agency, OneLegacy.
In Latin America, about 10 million to 12 million people are believed to
be infected with the Chagas parasite. As many as 1 million of them are
expected to die from the disease unless there are advances in treatment,
according to Dr. James Maguire, a University of Maryland expert on the
disease.
"Chagas is very, very prevalent in South and Central America," said
Marek Nowicki, a USC blood-disease expert who studied the effect of
Chagas on the Southern California organ supply with the National
Institute of Transplantation.
"The number of [immigrant] Latinos in Southern California, Texas and
other parts of the United States are growing, but especially in L.A., a
large proportion of organ donors are Latino," Nowicki said. "They're
basically bringing with them the disease prevalence in the area they
used to live."
The problem is not limited to immigrants. Tourists, too, can be
carriers. The heart transplant cases in Los Angeles last year illustrate
the problem.
One donor was a native of El Salvador living in Los Angeles, and the
other was born in the U.S. but had traveled to Guadalajara, Mexico,
where T. cruzi is endemic.
Richard Edward Russo, then 73, received the heart from the Salvadoran
native. The Burbank retiree appeared to be recovering nicely last year
when, several weeks after his transplant at St. Vincent Medical Center
in Los Angeles, he developed a fever and a rash. He complained of being
tired and couldn't eat or walk.
About the same time, a 64-year-old man developed similar symptoms after
receiving a transplant at UCLA Medical Center. He had received the heart
from the American tourist.
At both hospitals, doctors submitted the patients to a battery of tests,
concluding separately that they had Chagas.
The CDC sent anti-parasitic medication out from Atlanta. The drug
reduced the parasite in the blood of both men to undetectable levels.
But Russo never got better, his wife, Carolyn, said. He suffered from
other hospital-acquired infections and had pneumonia at least twice.
"It just went downhill," she said. Russo died in June 2006.
As a result of the cases, the CDC last summer warned doctors that the
prevalence of infection might be higher than previously thought,
especially in areas like Los Angeles County.
Chagas is a clear reminder that "diseases don't have geographic borders
anymore," said Dr. Suman Radhakrishna, an infectious diseases expert in
Los Angeles who helped treat Russo. Doctors need to be "cognizant that
diseases happening elsewhere in the world can happen in our backyard too."
Another disease, cysticercosis, caused by tapeworm larvae, is believed
to cause as many as 10% of the seizures reported to large urban
emergency rooms in California and New Mexico. Dr. Ashok Jain, a USC
emergency room doctor, said the figure may be as high as 20% at Los
Angeles County USC Medical Center.
It is spread through ingestion, not the blood or organ supply.
"When I was in Cook County in Chicago, I didn't even know it existed,"
said Jain, an associate professor of clinical emergency medicine at USC.
"Then I came to L.A. County … and oh, God, there were so many cases."
Diseases like Chagas and cysticercosis have emerged as an issue for some
opponents of illegal immigration, who argue that exotic diseases are
often spread by illegal immigrants.
"Curbing illegal entry will diminish the problem of exposure to such
diseases because legal immigrants are medically screened to protect the
U.S. public," said Jack Martin, special projects director for the
Federation for American Immigration Reform, an immigration control group..
Public health officials say the migration of diseases has always been an
issue — and is especially so today, in an increasingly mobile world with
a global economy. Many urge caution, not alarm.
"I don't want people to overreact, but I don't want people to ignore
it," said Victor Tsang, chief of the immunochemistry lab at the CDC's
Division of Parasitic Diseases. "The more we pay attention to it, the
better off we are."