I don’t know what an .img file is. If it is just raw sector data, that would be the same as the typical .dsk file. There are IMD files that some of the simulator devices support, though I prefer converting IMD to DSK, since nothing else (like PC2FLOP) support IMD.
AltairZ80, for example, supports the following disk controllers:
DSK (Altair)
DISK1A
DISK2
DISK3
IF3
CROMFDC
FIF
MDSK
MDSA
MDSAD
SCP300F
JADEDD
TARBELL
TDD
ICOM
DJ2D
DJHDC
If you have a CP/M image and the simulator has matching simulated hardware, it will more than likely run. If you email me a couple examples, I can see if they work.
With the exception of the JAIR, I don’t think any of the S100computers CF/SD CP/M images will currently work with the sim as they don’t provide any “standard” interface, though they could be made to.