After the article, I have included a link to where you can learn more
about OCT and its various applications.
Cancer Res. 2010 Mar 16. [Epub ahead of print]
Imaging of Human Lymph Nodes Using Optical Coherence Tomography:
Potential for Staging Cancer.
McLaughlin RA, Scolaro L, Robbins P, Hamza S, Saunders C, Sampson DD.
Authors' Affiliations: Optical + Biomedical Engineering Laboratory,
School of Electrical, Electronic, and Computer Engineering and School
of Surgery, University of Western Australia, Crawley, Western
Australia, Australia; and PathWest, QEII Medical Centre and Sir
Charles Gairdner Hospital, Nedlands, Western Australia, Australia.
Histologic assessment is the gold standard technique for the
identification of metastatic involvement of lymph nodes in malignant
disease, but can only be performed ex vivo and often results in the
unnecessary excision of healthy lymph nodes, leading to complications
such as lymphedema. Optical coherence tomography (OCT) is a high-
resolution, near-IR imaging modality capable of visualizing
microscopic features within tissue. OCT has the potential to provide
in vivo assessment of tissue involvement by cancer. In this
morphologic study, we show the capability of OCT to image nodal
microarchitecture through an assessment of fresh, unstained ex vivo
lymph node samples. Examples include both benign human axillary lymph
nodes and nodes containing metastatic breast carcinoma. Through
accurate correlation with the histologic gold standard, OCT is shown
to enable differentiation of lymph node tissue from surrounding
adipose tissue, reveal nodal structures such as germinal centers and
intranodal vessels, and show both diffuse and well circumscribed
patterns of metastatic node involvement. Cancer Res; 70(7); 2579-84.
Read more about Optical Coherence Tomography
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