PROPOSED : HD PEDIGREE DNA LINKAGE ANALYSIS RESEARCH

[Tomarctus SA 1]

As we all know, Canine hip dysplasia (CHD) is a prevalent,
debilitating, polygenic disease characterized by hip subluxation and
laxity which results in osteoarthritis.

What we should be looking at developing in South Africa is DNA testing
in offering an informative pedigree linkage analysis of CHD in
determining which Alaskan Malamutes is the carriers of the CHD genome
gene for illimunation from breeding programme.

We as breeders should actually stand together as on the long run it
will be to the benefits of us all going forward in improving our
breeding lines.

As we all know from research;

1. Breed 0.0 with 0.0 and have a 82% change of breeding non-dysplastic
off-spring.
2. Breed 0.0 with 1.1 or greater and have a 41% change of breeding non-
dysplastic off-spring.
3. Breed 1.1 with 1.1 or greater and have a 13% change of breeding non-
dysplastic off-spring.

At the end it is about removing the genome gene carriers in breeding
lines in working towards a possible 100% success rate.

How serious are you as a breeder in participating and don't we have a
problem in breeding programs within South Africa?

It will be interesting to know, from KUSA statistics, which matings
produced the highest dysplastic rate in their off-spring? Just
wondering if such information is available?

Let's be honest, having breed registration limitation linked to HD
ratings don't actually solve the underlying problem and cause.

Have you say!