I have only gone as big as 28mm RH knobbies, which have a decent amount of clearance but not what I would call a ton, at least for mud, so I think it would be tight if they are a true 2.2. I only have 42mm tires in right now but can measure the clearance later today if it is helpful as a data point.
Not that I know what I'm talking about WRT frame modifications, but I wonder if the thick steel pipes on the Drake would be amenable to a little bit of indenting for a smidge more clearance. I think there's more clearance on the NDS already so maybe just the DS chainstay. Please do not take this as advice though, I am a certified dummmy.
The advice to go 26" is intriguing - anyone have a spare cheap 26" disc wheelset??
Simon
Portland OR