Thoughts on some disc brakes:
Cable-actuated:
The primary selling point of Avid BB7 cable-actuated discs is that they're cheap; they appear to have no other redeeming qualities. They're fiddly to set up, fiddly to adjust, and actual braking operation is firmly mediocre.
TRY Spyre: they get a lot of positive talk on the internet due to their dual-piston actuation. I've put a ton of miles on them on my commuter, and I'm pretty close to throwing them in the bin. The caliper is cheaply made and pretty flexy; as a result the braking feel is less confidence inspiring than my old XTR canti brakes. There's no locking/retention feature on the pad adjusters and they'll back out over the course of a few rides if you try to use them.
I've heard very good things about the Paul Klampers. The beefy caliper should be very rigid, which is what you want in your brake system - the force you apply goes into stopping the bike, rather than flexing the brake system. The pad adjusters appear to be designed to be both easy to operate *and* secured against backing out. Fully rebuildable. If you're looking for the intersection of "great brakes" and "easy to adjust and maintain", these might be the ticket. But $$$...
Hydraulic:
TRP Hylex: As far as I know, these are the only hydraulic dropbar levers without integrated shifters (if I'm wrong, please let me know!). They have a really interesting hood/lever shape; it's a very long extension. It seems like a very polarizing love-it-or-hate-it shape, FWIW I love the feel in the hand. Very firm braking, just like you'd expect from a hydraulic setup. On the minus: More side-to-side play in the lever that I'd like; the bearing area on the pivots seems really narrow. Also seemingly impossible to bleed correctly? I do my Shimano MTB levers in my garage no problem; trying to bleed the Hylex brakes made me wonder if I'm actually an idiot. Took it to the shop for them to do, and they confirmed they're awful - the head wrench said it took him 9 tries to get it right. Disclaimer: These are my thoughts on the original Hylex. I think the only difference with the newer Hylex RS is the drilled brake lever, but maybe they improved stuff under the hood.
Shimano: My buddy has a bike with the R8000-series Ultegra hydraulic levers and brakes, and they've seemed pretty great on the few test rides I've taken. I expect that they'll be just as easy to bleed as the other Shimano hydraulics. Also, I'd expect that the shift mechanism in the levers is 100% non-rebuildable, just like all the other Shimano brifters. *shrugs*
Haven't tried SRAM hydraulics, but I recall they they had a series of recalls a few years ago. Also haven't tried any cable-actuated hydraulic calipers, so no opinion on those.
Hope this helps you make a decision;
-Adem Rudin
Mountain View, CA