There is a panaracer "gravel king" 650bx42 up on the panaracer site that is billed as having a bead to bead breaker and weighing 410 or so g. My shop couldn't order it or find it though, and instead got the pacenti pari-moto for me. The pari-moto's I have that are a few months old weigh 330g on my scale, and have a very thin breaker under the center smooth tread only. There is no way that the bead, or sidewall are tubeless compatible.
I bet the cannondale tire is really close to the "gravel king" 650x42.
I also have a set of g-one here that I'm undecided on running right now. They have a totallllly different casing and construction and are begging for tubeless, and engineered from the ground up for it.