I have done this with Nylon, mostly by accident as I was still figuring it out at the time.
The layer bonding between my first two layers was terrible as my bed and print temperature was too cool, but the first layer peeled away from the second very nicely. The rest of the layers were fine.
Later I used this 'feature' by printing a completely solid first layer, and then I started my through holes and such at the second layer. They turned out much better than trying to start them on the bed.
I do a similar thing when I need a bridge with a hole in the center. I model one layer as solid and start the hole above that. They turn out much better.