Kurt
Long ago I used Simplify-3d :-)
I have been using PrusaSlicer. Prusa puts a lot of work into presets for various filaments, and since my primary printer is the XL that works for me.
I also use it with PrusaConnect to send jobs to my XL over the cloud. I have also used PrusaLink for direct connection, but I dont do anything were I am worried about Prusa looking at it, even through I doubt they would.
The configuration available in it for my sons old MakerGear M2 also works well, and in that case I use its network ability to send jobs to my octoprint that talks to the MakerGear M2.
The avantage to OrcaSlicer is it has a lot of configuration support for tuning in filaments and printers. PrusaSlicer is more based upon downloading that stuff.
The biggest issue between the two is that Bambo based their slicer on PrusaSlicer making some seriously incompatable changes. Some were reasonable others not so.
One reasonable change is that prusaslicer has an older .ini model of configuration data, while Bambos is XML (or maybe Jason, not sure which at the moment).
Since Orca slicer is based upon Bambostudio it has those changes.
Of course features flow back and forth between the slicers since the code is public domain.
I could tell you I use
https://help.prusa3d.com/article/easyprint_898029 but I have done that just to play with it. It’s a webbased subset of PrusaSlicer. It’s kinda neat because it means for example a high school student could design a model in TinkerCad then load it into Easyprint slice it and print it, all from their tablet/smart-phone.
Considering your printer I would suggest OrcaSlicer. Though even though I have it, I prefer Prusaslicer. Oh - Prusa has said they are having a MAJOR release of Prusaslicer soon. I mean real major serious reworking of the UI etc. It’s gonna be release 3.0.
Kurt