If you have a lot of preference changes you can make them and then save the profile as a unique named profile... Such as "My Elegoo Centauri Carbon .04".. then when you want a different set of settings just pick that variant. I personally can't stand the the brim setting default. I turned it off and saved it as a "My" profile.
Otherwise I pretty much just just elegoo slicer because of its added functionality when sending files to trip the leveling routine or set the specific bed side.
Orca is more up to date and has a few more features but you're limited to not having that extra customization in the Elegoo variant.
I'm trying to work out a good profile for Simplify3d even though it's old and not as updated it's still my preferred slicer. Simplify sent me a base profile but when I did a test print it had a few issues in the post processing scripts that I need to sort through.