Fwd: PharmaCrunch Updates
praveen kumar
PharmaCrunch Updates
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List of Pharmaceutical journals with Impact factor Posted: 26 Jun 2011 12:51 PM PDT What is Impact factor? The impact factor is a measure of the frequency with which the “average article” in a journal has been cited in a given period of time Impact Factor, from where?
How it is calculated for a journal? The impact factor for a journal is calculated based on a three-year period, and can be considered to be the average number of times published papers are cited up to two years after publication. Calculation of impact factor For example, The “Impact Factor 2009” for a journal would be calculated as follows: X = the number of times articles published in 2007-2008 were cited in indexed journals during 2009 Y = the number of articles, reviews, proceedings or notes published in 2007-2008 Impact Factor 2009 = X/Y LIST OF JOURNALS
22.524 PHARMACOLOGICAL REVIEWS 17.013 TRENDS IN PHARMACOLOGICAL SCIENCES 11.959 ANNUAL REVIEW OF PHARMACOLOGY AND TOXICOLOGY 9.667 REVIEWS OF PHYSIOLOGY BIOCHEMISTRY AND PHARMACOLOGY 5.927 MOLECULAR PHARMACOLOGY 4.695 BRITISH JOURNAL OF PHARMACOLOGY 4.367 PHARMACOGENETICS 4.327 DRUGS 3.818 CLINICAL PHARMACOLOGY & THERAPEUTICS 3.800 PHARMACOLOGY & THERAPEUTICS 3.688 CRITICAL REVIEWS IN THERAPEUTIC DRUG CARRIER SYSTEMS 3.496 JOURNAL OF CLINICAL PSYCHOPHARMACOLOGY 3.323 JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS 3.308 DRUG METABOLISM REVIEWS 3.180 ANTIMICROBIAL AGENTS AND CHEMOTHERAPY 2.813 NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY 2.780 NEUROPSYCHOPHARMACOLOGY 2.677 EUROPEAN JOURNAL OF PHARMACOLOGY 2.634 CLINICAL PHARMACOKINETICS 2.549 PSYCHOPHARMACOLOGY 2.500 LIFE SCIENCES 2.490 TOXICOLOGY AND APPLIED PHARMACOLOGY 2.424 NEUROPHARMACOLOGY 2.279 ANNUAL REPORTS IN MEDICINAL CHEMISTRY 2.263 BIOCHEMICAL PHARMACOLOGY 2.228 JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY 2.110 ALIMENTARY PHARMACOLOGY & THERAPEUTICS 2.071 CLINICAL NEUROPHARMACOLOGY 1.958 ANTI-CANCER DRUG DESIGN 1.933 EUROPEAN NEUROPSYCHOPHARMACOLOGY 1.922 BRITISH JOURNAL OF CLINICAL PHARMACOLOGY 1.914 DRUG DELIVERY REVIEWS 1.901 ANTIVIRAL CHEMISTRY & CHEMOTHERAPY 1.838 PHARMACEUTICAL RESEARCH 1.825 JOURNAL OF AUTONOMIC PHARMACOLOGY 1.818 BEHAVIOURAL PHARMACOLOGY 1.699 DRUG METABOLISM AND DISPOSITION 1.680 JOURNAL OF CARDIOVASCULAR PHARMACOLOGY 1.600 PHARMACOPSYCHIATRIA 1.561 CHIRALITY 1.535 DRUG DEVELOPMENT RESEARCH 1.526 JOURNAL OF CONTROLLED RELEASE 1.510 NEUROTOXICOLOGY 1.507 QUANTITATIVE STRUCTURE-ACTIVITY RELATIONSHIPS 1.498 JOURNAL OF NATURAL PRODUCTS-LLOYDIA 1.481 CANCER CHEMOTHERAPY AND PHARMACOLOGY 1.450 PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR 1.439 PSYCHOPHARMACOLOGY BULLETIN 1.408 THERAPEUTIC DRUG MONITORING 1.397 TOXICON 1.382 FUNDAMENTAL & CLINICAL PHARMACOLOGY 1.373 ALCOHOL 1.364 INTERNATIONAL CLINICAL PSYCHOPHARMACOLOGY 1.344 CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY 1.310 JOURNAL OF PHARMACEUTICAL SCIENCES 1.308 JOURNAL OF PSYCHOPHARMACOLOGY 1.286 IMMUNOPHARMACOLOGY 1.284 JOURNAL OF PHARMACOKINETICS AND BIOPHARMACEUTICS 1.274 TOXICOLOGY 1.258 ANTI-CANCER DRUGS 1.234 REGULATORY TOXICOLOGY AND PHARMACOLOGY 1.195 JOURNAL OF ANTIBIOTICS 1.184 CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY 1.170 INTERNATIONAL JOURNAL OF IMMUNOPHARMACOLOGY 1.149 PULMONARY PHARMACOLOGY 1.141 PROGRESS IN NEURO-PSYCHOPHARMACOLOGY 1.133 XENOBIOTICA 1.099 CHEMICAL & PHARMACEUTICAL BULLETIN 1.094 DRUG SAFETY 1.080 DRUGS & AGING 1.078 PHARMACOLOGY & TOXICOLOGY 1.050 INTERNATIONAL JOURNAL OF PHARMACEUTICS 1.044 PLANTA MEDICA 1.038 EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY 1.019 PHARMACOLOGY 0.979 JOURNAL OF CLINICAL PHARMACY 0.977 BIOMEDICAL CHROMATOGRAPHY 0.975 CARDIOVASCULAR DRUGS AND THERAPY 0.932 JAPANESE JOURNAL OF PHARMACOLOGY 0.923 AGENTS AND ACTIONS 0.910 PHARMACEUTISCH WEEKBLAD-SCIENTIFIC EDITION 0.887 JOURNAL OF PHARMACY AND PHARMACOLOGY 0.854 HUMAN PSYCHOPHARMACOLOGY-CLINICAL AND EXPERIMENTAL 0.849 AMERICAN JOURNAL OF HOSPITAL PHARMACY 0.846 GENERAL PHARMACOLOGY 0.842 CHEMOTHERAPY 0.840 JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS 0.826 ANNALS OF PHARMACOTHERAPY 0.809 BIOPHARMACEUTICS & DRUG DISPOSITION 0.809 INVESTIGATIONAL NEW DRUGS 0.787 ARCHIVES INTERNATIONALES DE PHARMACODYNAMIE ET DE THERAPIE 0.780 RESEARCH COMMUNICATIONS IN CHEMICAL PATHOLOGY AND PHARMACOLOGY 0.778 JOURNAL OF PHARMACOLOGICAL AND TOXICOLOGICAL METHODS 0.75 PHARMACOTHERAPY 0.739 CLINICAL PHARMACY 0.730 BIOLOGICAL & PHARMACEUTICAL BULLETIN 0.696 FLUORIDE 0.688 BIOMEDICINE & PHARMACOTHERAPY 0.684 EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES 0.675 JOURNAL OF VETERINARY PHARMACOLOGY AND THERAPEUTICS 0.655 CLINICAL AND EXPERIMENTAL HYPERTENSION 0.653 IMMUNOPHARMACOLOGY AND IMMUNOTOXICOLOGY 0.647 JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS 0.623 COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-PHARMACOLOGY TOXICOLOGY & 0.597 SKIN PHARMACOLOGY 0.583 CLINICAL THERAPEUTICS 0.566 AMERICAN JOURNAL OF PHARMACEUTICAL EDUCATION 0.564 DRUG INVESTIGATION 0.539 ARCHIV DER PHARMAZIE 0.537 ARZNEIMITTEL-FORSCHUNG/DRUG RESEARCH 0.532 DRUG AND CHEMICAL TOXICOLOGY 0.500 JOURNAL OF ETHNOPHARMACOLOGY 0.489 EUROPEAN JOURNAL OF DRUG METABOLISM AND PHARMACOKINETICS 0.484 METHODS AND FINDINGS IN EXPERIMENTAL AND CLINICAL PHARMACOLOGY 0.482 DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY 0.460 PHYTOTHERAPY RESEARCH 0.453 ACTA PHARMACEUTICA NORDICA 0.446 PHARMACY WORLD & SCIENCE 0.442 JOURNAL OF CLINICAL PHARMACY AND THERAPEUTICS 0.442 JOURNAL OF MICROENCAPSULATION 0.436 CURRENT THERAPEUTIC RESEARCH-CLINICAL AND EXPERIMENTAL 0.424 INTERNATIONAL JOURNAL OF CLINICAL PHARMACOLOGY AND BIOPHARMACY 0.368 JOURNAL OF OCULAR PHARMACOLOGY 0.346 FARMACO 0.345 DRUGS UNDER EXPERIMENTAL AND CLINICAL RESEARCH 0.337 ASIA PACIFIC JOURNAL OF PHARMACOLOGY 0.337 JOURNAL OF PHARMACOBIO-DYNAMICS 0.334 PHARMAZIE 0.333 ADVERSE DRUG REACTIONS AND TOXICOLOGICAL REVIEWS 0.326 INTERNATIONAL JOURNAL OF IMMUNOPATHOLOGY AND PHARMACOLOGY 0.324 ADVANCES IN THERAPY 0.322 ACTA PHARMACOLOGICA SINICA 0.319 INTERNATIONAL JOURNAL OF CLINICAL PHARMACOLOGY RESEARCH 0.315 PHARMACOLOGICAL RESEARCH COMMUNICATIONS 0.299 THERAPIE 0.294 DEVELOPMENTAL PHARMACOLOGY AND THERAPEUTICS 0.284 JOURNAL OF INTERNATIONAL MEDICAL RESEARCH 0.282 JOURNAL OF THE AMERICAN COLLEGE OF TOXICOLOGY 0.280 CLINICAL TRIALS AND META-ANALYSIS 0.246 YAKUGAKU ZASSHI-JOURNAL OF THE PHARMACEUTICAL SOCIETY OF JAPAN 0.233 PHARMACOPEIAL FORUM 0.190 ACTA THERAPEUTICA 0.187 HOSPITAL FORMULARY 0.094 JOURNAL OF CHEMOTHERAPY 0.011 EOS-RIVISTA DI IMMUNOLOGIA ED IMMUNOFARMACOLOGIA 0.000 CLINICAL IMMUNOTHERAPEUTICS 0.000 CNS DRUGS 0.000 GENE THERAPY 0.000 RESEARCH COMMUNICATIONS IN MOLECULAR PATHOLOGY AND PHARMACOLOGY  |
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praveen kumar
From: Pharma Crunch <pharma...@gmail.com>
Date: Fri, Jul 1, 2011 at 4:04 PM
Subject: PharmaCrunch Updates
To: pravee...@gmail.com
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Caffeine, its Effect & Extraction Procedure Posted: 30 Jun 2011 10:12 PM PDT Brief about Caffeine:- A bitter alkaloid found in coffee and tea that is responsible for their stimulating effects.
In humans, caffeine acts as a CNS stimulant, temporarily prevent the occurrence of; drowsiness and restoring alertness. Caffeine is the world’s most widely consumed psychoactive substance, but, unlike many other psychoactive substances, is legal and unregulated in nearly all jurisdictions. Beverages containing caffeine, such as coffee, tea, soft drinks, and energy drinks, enjoy great popularity.
The U.S. Food and Drug Administration (FDA) lists caffeine as a “multiple purpose generally recognized as safe food substance”
Extraction of Caffeine
1:- Tea Leaves Extract {50g tea Leaves in 250 ml Solvent (Methanol/Water-Methanol Mixture)}
2:- Treated with excess amount of 2% Lead acetate (for complete removal of tannins) It will give pptn Filteration Filterate (Light yellow in colour) 3:- If colour is light brown then again treated with Excess amount of Lead Acetate Filteration Filterate (Light yellow in colour)
4:- Treated with Excess amount of dil. H2SO4 for removal of Excess of Lead Acetate (Filtration) 5:- Filtrate is treated with dil. Ammonia solution to maintain the pH at 7.0
6:- Neutralized filterate is extracted with Chloroform in Separating Funnel (3 times Extracted with Chloroform, 20 ml Each time) (Avoid the impurities present between the aqueous and CHCl3Layer)
7:- Mix the CHCl3 Extract and evaporate the solvent in Water bath. (Avoid charring of caffeine by excess evaporation)
8:- Crude Caffeine (Recrystallization by Methanol)
9:- Needle Shaped Caffeine crystals  |
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A new approach for Diabetes Care Posted: 30 Jun 2011 09:20 PM PDT By :- Subhi Sharma
Studies have shown that patients taking insulin degludec needed to take significantly smaller doses of basal insulin than those taking insulin glargine, while achieving similar blood glucose levels. Insulin degludec also has the ability to be mixed with other insulins, something that cannot be done using current long-acting insulins. Insulin degludec is currently in Phase III clinical trials, the final step before regulatory filing in the United States. Novo Nordisk hopes to begin marketing the novel insulin analog in 2013.
Here is a link in regards to this [updated on 24th June] Ultra-long-acting insulin degludec, under development, lowers blood glucose levels with significantly reduced rates of hypoglycaemia (low blood sugar) compared to insulin glargine, according to data presented at the 71st Scientific Sessions of the American Diabetes Association (ADA) in San Diego. Data were from two, phase three, 52-week clinical trials, one individuals with type 1 and one individuals with type 2 diabetes. Separately, in a late-breaking presentation, data revealed that insulin degludec could be dosed at different times from day to day in a 26-week trial. “Episodes of low blood sugar, known as hypoglycaemia, are a major concern for many people with diabetes,” said Alan Garber, MD, Professor, Departments of Medicine, Baylor College of Medicine, in Houston, Texas, USA. “It is particularly encouraging that insulin degludec significantly reduces the rate of overall hypoglycaemia in type 2 patients and nocturnal hypoglycaemia, in patients with type 1 or type 2 diabetes. The findings of these studies suggest that insulin degludec potentially offers substantial benefits for patients and the management of their diabetes.” Trials were ‘treat-to-target’ studies, meaning insulin was titrated systematically to achieve a target fasting glucose level. Patients in the open-label trials, using insulin degludec and insulin glargine had similar starting glucose levels, allowing researchers to closely determine the differences between the treatments.  |
Caffeine was first obtained in pure form from coffee in 1820 by the German chemist Friedlieb Ferdinand Runge
Diabetes MELLITUS IS THE THIRD LARGEST KILLING DISEASE NOW A DAYS .After cancer and cardiovascular diseases……..some herbal advancement such as momordica indica,termanalia chebula have known to reduce blood sugar but a new aid has been discovered by Novo Nordisk, Its an ultra long acting insulin named as Insulin Degludec over long acting Insulin glargine. (forms soluble multihexamer assemblies after subcutaneous injection) However with some disadvantages of this insulin as that it cannot be mixed with any other insulin preparation because it is not suitable at acidic pH…and also does not control meal time glycaemia.It is injected subcutaneously three-times a week to help control the blood sugar level of those with diabetes. Its advantage is that it has a duration of action that lasts up to 40 hours, unlike the 18 to 26 hours provided by current marketed long-acting insulins such as Insulin glargine and Insulin detemir.| You are subscribed to email updates from Pharma Crunch
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