Hacking /Ourselves/ to extend lifespan.

4 views
Skip to first unread message

ad...@reviews.wox.org

unread,
Jan 10, 2022, 7:51:51 PMJan 10
to 2600-au...@googlegroups.com

To  be totally random here -
An interesting coincidence in 2019 (about a week before covid was in all the headlines) a Professor David Sinclair after about 25+ years of research into aging, concluded an experiment he had been working on with mice that effectively proved that age could be slowed, cured or even reversed - and announced the fact. Thanks to covid this never made any headline.

We don't need to grow older any more gents(and lasses)


======================================================
I've summarised all I know about the actual mechanics of it below.
======================================================

He (Prof Sinclair) had also been using some of the less invasive treatments on himself and his researchers families for over a year too by that point since it was pretty harmless.

Using the treatment on some of the older wives of his lab staff - they discovered another interesting side effect that nobody had expected given the usual thinking on the topic - it also reversed menopause.  This came as quite a surprise to most as everyone had been taking it for granted a women doesn't create new eggs.  Apparently this was incorrect. It was simply an assumption that nobody had bothered to double check in modern times. Science is important, as is questioning it!

Using the treatment on himself he found that it took roughly 6 months of treatment to repair cell damage and revert his cellular age from about 52 to 32.   This figure is very interesting, as one of the primary causes of aging he identified, as far back as 2016 maybe more was that the mechanism in cells, which he called sirtuins which protects them from damage (ie aging is that damage)  is redirected if the body detects fragments of mDNA and  reacts.    The sirtuins then attempt to collect and repair/reintegrate/deal with broken mDNA fragments.  While it performs this function their normal cellular repair/protection mechanism stops working.  In effect if you have too many mDNA fragments in your body, you age faster. Progeria.


As for the treatment itself it involves a few steps. 
To simply slow down aging you need to:

  • increase the NAD levels in your body.    This can be done using nicotinamide supplements - which are in many multivitamins or you can buy it by itself from coles supermarkets.  This increases a cells resistance to damage, and promotes increased blood flow. It helps create additional sirtuins which add resistance to cell damage. There was also a link between nad+ and epigenomic modes of cells.
  • increase Resveratrol levels in your body.  This allows the cell to recover/resist from existing damage in your cells. This too can be purchased as supplements, and exists in real red wine if you have a glass with dinner. (It is not in the fake crap that is basically wine flavoured sulphate cordial and ethylated spirits mixed in the factory that 90% of most wines actually is however so buyer beware)
  • change your diet to a low sugar low protein diet - this forces your body into survival mode and it hunkers down to resist cellular damage associated with aging, (also lose weight, although the above steps cause that as a side effect anyway - increased blood flow has the same effect as taking a 15 minute walk every day)
  • Although not as effective as originally thought, antioxidants don't hurt either, and Resveratrol is a form of one anyway.

To also stop and even reverse aging you need to:

  • exercise more - this adds endurance and flexibility to your cells, and can increase the telomere in some of your cells
  • gene therapy to flip on several key gene expressions, and epigenomic modes including one that regenerates the telomere in your cells, preventing them from going into cell senescence mode if they run out where they basically become dead weight and make you age faster.  The telomere link was established back in 2014-15 and a biotech company CEO by the name of Elizabeth Parrish (also a big name in age research) commissioned a retrovirus to turn those very genes on in herself.  Combined with Professor Sinclair's  research she may be one of the first humans to never age. Ever.
  • reverse or eliminated senescent cells that have built up in the body as a result of time.


=================
Other issues in play -
=================

The concern is in a world where nobody grows old population may be a problem.  However it has been pointed out that people would still die from accidents, conflict and disease.  In most cases deaths associated with old age are actually underlying medical conditions anyway. Up to recently coroners were just lazy in reporting the actual cause.   In practice the main impact this treatment would have is that those of old age would have quality of life not just long life. A 90 year old would have the health potentially of a 30 year old - although complications may still eventually lead to the conclusion of their life, they would be less likely to die alone and in pain.

In essence, the main side effect of mDNA fragment based vaccinations is highly likely to involve significantly accelerated aging type cellular damge in humans.

NASA has been experimenting with NAD+ treatments for astronauts to reverse damage from cosmic radiation.  Also in space Telomere naturally expands. They are not entirely sure why.   Refer the NASA twin experiment.  But it seems a human space civilisation would naturally have expanded life spans anyway.  Interesting.

Many conditions related to eyesight, cancer and organ failure are actually just the physical manifestations of cell senescence, this treatment even at a small scale (gene therapy is hard!) could be used to give some people back their eyesight, hearing or mobility - and prevent some people getting many forms of cancer to begin with - or eliminate some forms of cancer they already have.  Experiments in this direction has already bourne fruit.

Many medical conditions that attract high funding (heart disease, lung problems, retarded organ function) would be eliminated entirely if the patient had started this treatment from an early age.   Researchers tend to have tunnel vision and they may try to resist the loss of their funding.

On top of that pharma companies who rely on profit from the misery of endless treatment of symptoms would resist this for all but their own board of directors viciously too.  (which might explain the convenient "mDNA" side effect of the vaccines)

Extended life will not necessarily extend the life of your brain, so active minds would be of high importance too.


=============
Tin foil cap time
=============

Putting our tin foil caps on for a moment- What makes this so very interesting is several coincidences -

  • The main cause of Progeria (a condition which causes accelerated aging) is too much damaged and fragmented mDNA in the body.
  • Injecting yourself with mDNA fragments will artificially create the conditions for Progeria in a healthy person. This was confirmed in one of the mouse experiments. Young mice with fragmented mDNA developed Progeria like symptoms, and aged at an accelerated rate. They looked old too, and died prematurely.
  • It takes roughly 6 months of treatment to reverse the damage to your cells caused by aging (and/or Sirtuins reacting to nDNA fragments in the body)  this was also indirectly confirmed in the mouse experiment(and the researchers experimenting on themselves), elderly mice were found to have enough stamina to run for several KM's - more even than younger mice - and still looked young.
  • mDNA based vaccines are mandated to be given every 6 months and will cancel out many of the effects of any age reversal treatment - which also takes 6 months to work. Strange coincidence there.
  • The cov-19 variant of cov-2 virus was created originally to mass produce vaccines then "accidentally" escapes virtually the moment it is announced nobody needs to grow old anymore - preventing the announcement from making any headlines and its main treatment is a vaccine that stops that same age prevention treatment from even working?  oooook.
  • If you search for Prof Sinclair, google mysteriously goes out of its way to avoid showing any results about him. You need to add keywords like aging or his full name to get any meaningful results.  o_O

Ok enough with the tin foil hat shit.

Makes you go Hmmm tho yes?



-- 
New and improved 2600... well..  ..we drew on some flames and polished it a bit..
--
Google - making sure, life is no more, than 1984...
--
Bill Gates: 640k is more than enough for anybody
--
In politics - Later never happens.

ad...@reviews.wox.org

unread,
Jan 10, 2022, 8:06:20 PMJan 10
to 2600-au...@googlegroups.com
A quick little addendum here -  the "survival mode" was more important than my original post suggested.  Professor Sinclair went on to point out we should try to trigger this mode as aggressively as possible as this too could flip some of the genetic switches without needing more complex gene therapy..

Suggestions he made in this regard was:

  1. Exercise (as in OP) although NAD naturally has exercise like side effects anyway.
  2. Expose your body to extremes.   Swim in cold water, have cold showers, or alternately really hot baths or showers.  Keep in mind tho that too much heat or cold can have other odd effects, and some physiologies (low/high blood pressure for example) may react badly.
  3. fasting - go for small periods without food, always end a meal feeling slightly hungry

The key take away point here is that the right types of stresses on your body flip genetic switches that extend your life span.

David Fernée

unread,
Jan 10, 2022, 9:07:04 PMJan 10
to 2600-au...@googlegroups.com
The Movies
This one came out in 2011: In Time (2011) - IMDb - Humans wanting to be immortal.
This one came out in 1999: Bicentennial Man (1999) - IMDb - A machine wanting to be mortal.

Philosophy
This Open Yale Course is good: Death | Open Yale Courses.
This might point to something interesting as well: Introduction: Philosophy of Death - Oxford Handbooks.

- If you could live forever, what would that mean and would you want to? Who lives, who dies, who decides?

Religions
What is ultimate reality (Ultimate reality - Wikipedia)?

Life Expectancy
This seems to look pretty good for Australia when compared with other parts of the world: Deaths in Australia, Life expectancy - Australian Institute of Health and Welfare (aihw.gov.au).
Table 6.3: Life expectancy (years) at birth, top 10 OECD countries by sex, 2018
Rank

Country

Males

Country

Females

Country

Persons

1

Switzerland

81.9

Japan

87.3

Japan

84.2

2

Iceland

81.3

Spain

86.3

Switzerland

83.8

3

Italy

81.2

France

85.9

Spain

83.5

4

Japan

81.1

Korea

85.7

Italy

83.4

5
Norway

81.1

Switzerland

85.7

Iceland

82.9

6

Israel

80.9

Italy

85.6

Israel

82.9

7

Sweden

80.9

Australia

84.9

Australia

82.8

8
Australia
80.7
Israel
84.8
France
82.8
9
Spain

80.7

Luxembourg

84.6

Norway

82.8

10
Ireland

80.5

Finland

84.5

Korea

82.7

11

Netherlands

80.3

Iceland

84.5

Sweden

82.6

12

Luxembourg

80.1

Norway

84.5

Luxembourg

82.4


--
--
------------------------------------------------------------
You received this message because you are subscribed to the "2600 Australia" group.
To post, send email to: 2600-au...@googlegroups.com
To subscribe, send email to: 2600-austral...@googlegroups.com
For 2600 monthly meetings, visit http://www.2600AU.org
For more options, visit this group at http://groups.google.com/group/2600-australia
To unsubscribe, send email to: 2600-australi...@googlegroups.com
Disclaimer: Comments to this mailing list are owned by the poster
------------------------------------------------------------
---
You received this message because you are subscribed to the Google Groups "2600 Australia" group.
To unsubscribe from this group and stop receiving emails from it, send an email to 2600-australi...@googlegroups.com.
To view this discussion on the web visit https://groups.google.com/d/msgid/2600-australia/4fb41b52-78b2-fd3e-f25d-a2671fbc9da2%40reviews.wox.org.

ad...@reviews.wox.org

unread,
Jan 11, 2022, 6:30:10 PMJan 11
to 2600-au...@googlegroups.com
o_O  an intellectual response...

The Timberlake movie 'in time' was a good example and covered another approach.  In that movie the wealthy can live forever.  But eventually some feel like they have done everything they can with their life; and choose to end it.     Because they can transfer their available time to another person, if they are not selfish, they can choose to end their life by giving their remaining time to others. Or the subtext not really explored was if they are just assholes they can stockpile an entire nation worth of peoples lifespans, then kill themself - and impoverish their nation in the process. 

On the flip side there was a "system" in place that permanently tried to prevent all but the top 3% from being able to live more than a few years, of enforcers and sanctioned criminals seizing peoples time under any shallow pretext. Many of the bottom 90% having less than a day, and had to work or their time would run down and kill them.  This means for some catching a cold would be fatal, (although i think a plot device was nobody got sick in that movie)

Considering covid in today's society - where a sick or non-immunised person is effectively thrown out of society and the workforce - and many end up losing their job, home and in some cases life (suicide, destitution, starvation, or complications from the virus) because of the disruption - society today is a good example of at least some of the implications of a world where if you cant work (because of illness, lack of jobs etc) you die.

In another approach, people in a civilisation that need not die, eventually are tired of life and end it on their own terms.     This is probably going to be the biggest moral disruption to peoples philosophy - and was touched on in the book by the scientist who made the announcement.  In Australia - Victoria already has assisted suicide laws.    The irony is the laws are already in place.

Also in the movie 'in time', there was actually more than enough "time" for the entire world to live as long as they liked, and the "time stockmarket"   much like fiat was an artificially created scarcity.    They could have just as easily set everyone's timer to infinity at the press of a button.

Between the lines in the story however was the cult of Malthus anti-humanist thinking had corrupted the politics of the society.  In essence, if you remove all the rhetoric - Thomas Malthus holds that there are limited resources, and the poor should be forced to die of illness, injury and war to free up those resources in the service of the wealthy who feel that they are entitled to them.     This led directly to the policies that killed millions in the irish potato famine, led to decades of forced post and pre-birth abortions in China under the one child policy that nearly brought their economy to its knees, was one of the primary driving forces behind the Pol Pot Massacres - and many other war crimes indirectly such as the death camps and ethnic cleansing.

For me the worst crimes in history have been made in the service of the cult of Malthus.

The problem with this is of course, in a high tech society it soon becomes apparent we live in a universe of effectively infinite space and resources - and forcing populations to be killed off instead of focusing on expanding into space assures that we will never actually make it to space - which it appears is what was wrong with the world depicted in the 'in time' movie.

In a society were everyone lives forever, the only solution is either the destruction of that society, or the society expands into the infinity of space.      There is no middle ground.    We cant even be sure if either approach would be a utopia or dystopia.  But a utopia is more likely with the removal of the shackles of scarcity.  But that also gives unlimited potential to any tyrant too, and just as likely mini dystopias would form.

In either case, trying to restrict it will always end in a Dystopia.   Just look at the world today.



On 11/01/2022 1:06 pm, David Fernée wrote:
The Movies
This one came out in 2011: In Time (2011) - IMDb - Humans wanting to be immortal.
This one came out in 1999: Bicentennial Man (1999) - IMDb - A machine wanting to be mortal.



-- 
New and improved 2600... well..  ..we drew on some flames and polished it a bit..
--
Google - making sure, life is no more, than 1984...
--
In politics - Later never happens.
Reply all
Reply to author
Forward
0 new messages