Database of human Protein-DNA Interactions - hPDI
biointelligence
The characterization of the protein-DNA interactions usually requires three levels of analysis:
1.Genetic: Determination of the nucleotide sequence of the protein-binding region and the identification of sequence changes that confer a mutated phenotype.
2. Biochemical: Identification of potential protein-DNA contacts using a variety of footprinting and protection experiments such as DNaseI or hydroxyl radical footprinting, and methylation protection or ethylation protection experiments.
3. Physical: Analysis of specific interactions in protein-target sequence fragment co-crystals.
The hPDI database holds experimental protein-DNA interaction data for humans identified by protein microarray assays. The current release of hPDI contains 17,718 protein-DNA interactions for 1013 human DNA-binding proteins. These DNA-binding proteins include 493 human transcription factors (TFs) and 520 unconventional DNA binding proteins (uDBPs). This database is freely accessible for any academic purposes.
hPDI can be accessed from here: http://www.xiezhi.org/hpdi-database
Team Biointelligence
Getting started with biosciences
Website: www.biointelligence.in
Email: in...@biointelligence.in
Tel: +91-731-425-7930
P please consider the environment before printing this email. Thank you.2