Are you editing this file by hand? Because the nesting here does not seem to be correct. You have:
horizontal box sizer
sizer item #1
box sizer (unknown orientation)
sizer item #2
vertical box sizer
sizer item #3
static text
sizer item #4
wxChoice
The problem here (which is difficult to see with the spacing) is that the wxChoice sizer item #4 is nested inside sizer item #2. The sizer items should all be peers of each other, and each sizer item should contain exactly one control. I can't tell what layout you're really looking for here; is the wxChoice supposed to be inside of the vertical box sizer, or in the outer one? And why do you have the extra sizer inside the horizontal box?
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