ABO compatibility in FFP

[chi...@aol.com]

Hey guys
P/s can somebody help me with this burning question, my brain just can't figure it out.

Since blood type O has anti-bodies to both A and B blood, why is it then the universal recipient when it comes to plasma transfusion?

Does this mean that a type O person can receive a Type A or B FFP? If so, why?

Please advice
Petronilla

[mariah dillon]

Type O is the universal DONOR of WHOLE BLOOD....it has no antigens on the surface of the cell.  It is a universal RECIPIENT of PLASMA for that same reason, it has no antigens, so the antibodies in plasma from other blood types won't cause hemolysis of the Type O cell.  Hope that helps.

[mariah dillon]

Not whole blood, i meant PRBC'S.  Whole blood has everything.  We separate whole blood into PRBC'S, PLASMA, PLATELETS.  You know that, I just wanted to clarify!

[Ivana Stefanovic]

 
Recipients can receive plasma of the same blood group, but otherwise the donor-recipient compatibility for blood plasma is the converse of that of RBCs: plasma extracted from type AB blood can be transfused to individuals of any blood group; individuals of blood group O can receive plasma from any blood group; and type O plasma can be used only by type O recipients.
 
There is a table here  - http://en.wikipedia.org/wiki/Blood_type#Plasma_compatibility
 
Have fun :)

Plasma compatibility table^[61]

Recipient	Donor[1]
	O	A	B	AB
O	Y	Y	Y	Y
A		Y		Y
B			Y	Y
AB				Y

Plasma compatibility table^[61]

Recipient	Donor[1]
	O	A	B	AB
O	Y	Y	Y	Y
A		Y		Y
B			Y	Y
AB				Y

 
Ivana

---

To: umbsr...@googlegroups.com
Subject: ABO compatibility in FFP
From: chi...@aol.com
Date: Mon, 1 Nov 2010 20:15:29 -0400

[chi...@aol.com]

Thank you so much Mariah
I'm still confused though.  Why wouldn't their be a hemolysis if it's receiving type A or B plasma that it has anti-bodies to since anti-bodies are present on the plasma cell surface.My understanding is that Type O blood is a universal donor when it comes to PRBC transfusion b/cos it has no antigens and that's what you're dealing with when it comes to RBC's. However, it has anti-bodies to both A and B on it's plasma. 

[chi...@aol.com]

Thank you so much Ivana and Mariah, I appreciate all the help

Petronilla

-----Original Message-----
From: Ivana Stefanovic <ivan...@hotmail.com>
To: umbsrna2012 <umbsr...@googlegroups.com>

[mariah dillon]

Type O blood has RBC's without antigens.  It also has plasma that contains A and B antibodies.  So, If you give type A blood which has B antibodies in its plasma (only giving the plasma, not the RBC's), it will not harm the patient because the patient is already "conditioned" to type B antibodies. 

The same for giving type B blood plasma (the plasma has A antibodies), the patient is "conditioned".

 

However, you cannot give A, B, AB RBC's to the O type patient.  The patients A and B antibodies will cause hemolysis with the A, B, AB antigens. 

 

 

 

The same with type B blood which has A antibodies.  It will not harm the patient.  The patient is "conditioned" to type A antibodies.

[chi...@aol.com]

Thanks a million Mariah Ivana and Amy, makes absolute sense now

Sent from my BlackBerry® smartphone with Nextel Direct Connect

---

From: mariah dillon <magnol...@gmail.com>

Sender: umbsr...@googlegroups.com

Date: Mon, 1 Nov 2010 21:03:23 -0400

To: <umbsr...@googlegroups.com>

ReplyTo: umbsr...@googlegroups.com