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Dear James Martin
We heartily invite you to participate in the BCSSS Lecture Series on Systems Science and Medicine 2015, chaired by Prof. Dr.Dr.Dr. Felix Tretter.
The Bertalanffy Center for the Study of Systems Science welcomes Dr. Jörg Menche on Friday, April 24th 2015 at 2pm, Paulanergasse 13/5, 1040 Vienna, Austria, with his contribution "Diseases in the human interactome".
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Dr. Menche is a postdoctoral fellow with Prof. Albert-László Barabási at the Technical University of Budapest. From 2010 to 2012 he was an affiliated member of the Center for Cancer Systems Biology, Dana Farber Cancer Institute, at the Harvard Medical School, Boston, USA and a postdoctoral fellow with Prof. Albert-László Barabási at the Center for Complex Network Research at the Northeastern University, Boston, USA. He received his PhD in theoretical physics at the Max-Planck-Institute of Colloids and Interfaces (MPIKG) and the University of Potsdam, Germany (grade "Summa Cum Laude").
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Diseases in the human interactome
Recent advances in disease gene identification and high-throughput mapping of physical interactions between gene products offer new opportunities to explore the role of molecular networks in human disease.
In this Network medicine lecture Dr. Menche discusses recent findings on protein-protein interaction networks and disease relationships. He will show that proteins associated with the same disease display a statistically significant tendency to agglomerate in the same neighbourhood of the interactome, offering quantitative evidence for the existence of well-localized and potentially identifiable disease modules.
Most important, his research team1 found that the network-based location of each disease module determines its pathobiological relationship to other diseases. For example, disease pairs with overlapping modules show significant co-expression patterns, symptom similarity, and comorbidity; those that reside in separated network neighborhoods are pathobiologically and clinically distinct. The proposed interactome-based framework offers systematic avenues to discover common molecular roots between clinically unrelated disease phenotypes even if they do not share disease genes, and helps identify the biological role of GWAS (genome-wide association study) genes of small effect size and low genome-wide significance.
1 Jörg Menche, Amitabh Sharma, Maksim Kitsak, Susan Dina Ghiassian, Marc Vidal, Joseph Loscalzo & Albert-László Barabási from the Center for Complex Networks Research and Department of Physics, Northeastern University, Boston, USA; Center for Cancer Systems Biology (CCSB) and Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, USA; Center for Network Science, Central European University, Budapest, Hungary; Department of Genetics, Harvard Medical School, Boston, USA; and the Department of Medicine, Brigham and Women’s Hospital, Harvard Medical School, Boston, USA.
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Systems Medicine and Healthcare Systems at the Bertalanffy Center for the Study of Systems Science
Systems science applications in medicine are known since the 1950s when Ludwig von Bertalanffy was elaborating his general theory of living systems. At present, by new technological and formal methods in modern biology and medicine this perspective gets new support.
In order to stimulate this development of interdisciplinary discussion between medicine, systems biology, informatics and systems science several lectures are organized by the BCSSS, chaired by BCSSS Fellow Prof. Dr.Dr.Dr. Felix Tretter, in spring / summer 2015 at the Bertalanffy Center for the Study of Systems Science, Paulanergasse 13/5, 1040 Vienna, Austria.
Further lectures are planned for May and June 2015. Together with Prof. Tretter the Bertalanffy Center intends to establish a Research Group to investigate these future potentials. These open meetings mark unique opportunities for researchers and students from a variety of disciplines and representatives from industry, and from the private and governmental health care and insurance system to connect with us.
If you are interested to join, please, send a message to stefan.bl...@bcsss.org. Please feel free to forward this invitation.
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Further information about Systems Medicine at the BCSSS
Maintenance of health and the development of diseases are the result of complex dynamic interactions from the level of inter- and intracellular molecular networks of the cell to the levels of the interdependence of humans and their environments.
The first step towards systems medicine intended a better understanding of functions and dysfunctions of the organism by using computer simulations and data integration. At present, also clinical systems medicine is constituted to develop innovative therapies and personalized tailored preventive treatments. The future outlook is a scenario in which the health care system itself might change based on these findings.
Read more ...
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We are looking forward to meet you soon in Vienna.
Best regards,
Stefan Blachfellner
Managing Director, BCSSS
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