info
Google Groups no longer supports new Usenet posts or subscriptions. Historical content remains viewable.
Dismiss
Dietary amelioration of locomotor, neurotransmitter and mitochondrial aging.
11 views
Skip to first unread message
Olafur Pall Olafsson
Feb 21, 2012, 10:36:55 PM2/21/12
to
Exp Biol Med (Maywood). 2010 Jan;235(1):66-76.
Dietary amelioration of locomotor, neurotransmitter and mitochondrial
aging.
Aksenov V, Long J, Lokuge S, Foster JA, Liu J, Rollo CD.
Source
Department of Biology, McMaster University 1280 Main St W, Hamilton,
Ontario, Canada.
Abstract
Aging degrades motivation, cognition, sensory modalities and physical
capacities, essentially dimming zestful living. Bradykinesis
(declining physical movement) is a highly reliable biomarker of aging
and mortality risk. Mice fed a complex dietary supplement (DSP)
designed to ameliorate five mechanisms associated with aging showed no
loss of total daily locomotion compared with >50% decrement in old
untreated mice. This was associated with boosted striatal neuropeptide
Y, reversal of age-related declines in mitochondrial complex III
activity in brain and amelioration of oxidative stress (brain protein
carbonyls). Supplemented mice expressed approximately 50% fewer
mitochondrial protein carbonyls per unit of complex III activity.
Reduction of free radical production by mitochondria may explain the
exceptional longevity of birds and dietary restricted animals and no
DSP is known to impact this mechanism. Functional benefits greatly
exceeded the modest longevity increases documented for supplemented
normal mice. Regardless, for aging humans maintaining zestful health
and performance into later years may provide greater social and
economic benefits than simply prolonging lifespan. Although
identifying the role of specific ingredients and interactions remains
outstanding, results provide proof of principle that complex dietary
cocktails can powerfully ameliorate biomarkers of aging and modulate
mechanisms considered ultimate goals for aging interventions.
PMID: 20404021
Related citations
Time-course of mitochondrial gene expressions in mice brains:
implications for mitochondrial dysfunction, oxidative damage, and
cytochrome c in aging.
[J Neurochem. 2005]
A complex dietary supplement extends longevity of mice.
[J Gerontol A Biol Sci Med Sci....]
A dietary supplement abolishes age-related cognitive decline in
transgenic mice expressing elevated free radical processes.
[Exp Biol Med (Maywood). 2003]
Review Structural and functional changes in proteins induced by free
radical-mediated oxidative stress and protective action of the
antioxidants N-tert-butyl-alpha-phenylnitrone and vitamin E.
[Ann N Y Acad Sci. 1998]
Review The effect of long-term dietary supplementation with
antioxidants.
[Ann N Y Acad Sci. 1998]
Free full text article: http://ebm.rsmjournals.com/content/235/1/66.long
Dietary amelioration of locomotor, neurotransmitter and mitochondrial
aging.
Aksenov V, Long J, Lokuge S, Foster JA, Liu J, Rollo CD.
Source
Department of Biology, McMaster University 1280 Main St W, Hamilton,
Ontario, Canada.
Abstract
Aging degrades motivation, cognition, sensory modalities and physical
capacities, essentially dimming zestful living. Bradykinesis
(declining physical movement) is a highly reliable biomarker of aging
and mortality risk. Mice fed a complex dietary supplement (DSP)
designed to ameliorate five mechanisms associated with aging showed no
loss of total daily locomotion compared with >50% decrement in old
untreated mice. This was associated with boosted striatal neuropeptide
Y, reversal of age-related declines in mitochondrial complex III
activity in brain and amelioration of oxidative stress (brain protein
carbonyls). Supplemented mice expressed approximately 50% fewer
mitochondrial protein carbonyls per unit of complex III activity.
Reduction of free radical production by mitochondria may explain the
exceptional longevity of birds and dietary restricted animals and no
DSP is known to impact this mechanism. Functional benefits greatly
exceeded the modest longevity increases documented for supplemented
normal mice. Regardless, for aging humans maintaining zestful health
and performance into later years may provide greater social and
economic benefits than simply prolonging lifespan. Although
identifying the role of specific ingredients and interactions remains
outstanding, results provide proof of principle that complex dietary
cocktails can powerfully ameliorate biomarkers of aging and modulate
mechanisms considered ultimate goals for aging interventions.
PMID: 20404021
Related citations
Time-course of mitochondrial gene expressions in mice brains:
implications for mitochondrial dysfunction, oxidative damage, and
cytochrome c in aging.
[J Neurochem. 2005]
A complex dietary supplement extends longevity of mice.
[J Gerontol A Biol Sci Med Sci....]
A dietary supplement abolishes age-related cognitive decline in
transgenic mice expressing elevated free radical processes.
[Exp Biol Med (Maywood). 2003]
Review Structural and functional changes in proteins induced by free
radical-mediated oxidative stress and protective action of the
antioxidants N-tert-butyl-alpha-phenylnitrone and vitamin E.
[Ann N Y Acad Sci. 1998]
Review The effect of long-term dietary supplementation with
antioxidants.
[Ann N Y Acad Sci. 1998]
Free full text article: http://ebm.rsmjournals.com/content/235/1/66.long
Paul Antonik Wakfer
Feb 22, 2012, 1:19:06 AM2/22/12
to
--
--Paul Wakfer
MoreLife for the rational - http://morelife.org
Reality based tools for more life in quantity and quality
The Self-Sovereign Individual Project - http://selfsip.org
Self-sovereignty, rational pursuit of optimal lifetime happiness,
individual responsibility, social preferencing & social contracting
0 new messages