If you are using Shen/SBCL and driving your program from Python, then this is really a question of how you call SBCL from Python. An alternative might be to use Shen/Python which will require no FFI. However Ramil, the author of this port, would have to fill in the details of how you call a native Python function from his port. It would be good to know this and then I would put this info into the Learn Shen pages.
Such an arrangement, though simpler, might have a performance hit because Python is slower than SBCL - last time I looked (2007) by an order of magnitude.
Mark