Hi Mark,
Thanks for filing this as internal FB bug too!
In terms of TokuDB behavior I believe by default software should either work well or fail (preferably with clear error message about what has to be fixed). Right now jemalloc and THP are requirements for TokuDB and behavior when these are not enabled is not something which was validated to the point we want to support it.
"Do not mind wasting more RAM" can be dangerous proposition for users - observing things work with small test some can put software in the production where it can show very poor performance causing system swapping or crashing out of memory - not something most will appreciate.
Now I with MySQL Plugin Interface would allow more simple installation of bunch of plugins together as some sort of "plugin package" and allow to provide output directly to the user about requirements and failures, unfortunately it does not allow it at this point, this is why we've implemented ps_tokudb_admin to check requirements for most common use case.
I recognize you have pretty special case and requirement and I will check if we can implement "Mark Callaghan" option to bypass safety checks :)