Implemented fixes and my speed score is worse?

[Nat M]

After testing my site and getting a full report of recommendations, I implemented most of the suggested fixes and my new score is worse than the original! I went from a 59 to a 52 on desktop. 
The changes have registered on the Google PageSpeed test site so I only have one critical recommendation left (instead of 4 that I started with.)
 
Has anyone else come across this/ know what's going wrong?

[Emmanuel Galván]

We'll be able to help you better if you tell us what was your optimization settings before, what changed, and how are you optimizing (via mod, htaccess, cdn, etc.)

[Kenneth H]

please provide additional information if you would like assistance.