John:
From my experience import problems are sometimes related to file size and sometimes related to the idiosyncrasies of the format of the data being imported, and sometimes available memory. Owen Stephens has mentioned on this list his observation that as a dataset becomes wider (more columns) the odds of having a data import problem increase. That said, I don't have an immediate answer to your problem. Maybe you can give a bit more information.
So a few questions...
Is the small 4mb file a derivative of the big file? I'm trying to understand if you can open any file, or if it's just this file, regardless of the size.)
Can you import a very plain CSV file?
How many columns exist in the problem dataset?
Can you import or open the problem dataset in Excel?
There is also the possibility if increasing the default RAM setting. Some information about that is available in the
FAQ
--John Little