I checked my datasheet, and confirmed neon bulbs have an average rated lifespan of 25,000 hours at recommended current. This is about 3 years of continuous operation, so it seems very plausible to me that if an NE-2 bulb dies after 3-4 years, it's normal.
The lifetime is a statistical average; some bulbs will last longer, and some shorter. My 'big clock' has 304 NE-2 bulbs, and after nearly 4 years of operation I've had one premature bulb failure (in this clock, bulbs are 'on' for a maximum of 1.3 hours/day which equates to 50 year lifespan on average). There's nothing wrong with the design or manufacture of this clock; it's just an oddball lamp that failed.
In a different clock, I've also had an NE-2 fail after about 3 years. This bulb is always on, so I'd say it failed as expected.