Hello Benjamin,
I run Arch but I am on vacation and on my phone. Yet I feel a bit concerned obviously. A couple of ideas:
Have you tried removing the libguile .so 22 file, perhaps the entire folder then reinstalling libguile?
What's the package source for mu4e? Is it coming from AUR ? If yes which one ? Have you tried fetching mu4e directly from github and compiling it on your system ?
It's worth noting that if libguile's latest version is problematic then everybody here will soon know...
Best,
Charles.