That doesn't happen on most mod_pagespeed sites. If you think the module could add some value for your site, then perhaps it is worth tweaking some settings to tune it for your workload.
Can you describe more about your workload? Qps? Size of site overall? What hw is your server running on?
What version of MPS? What does your config look like?
Probably a slow disk means you are thrashing the MPS file cache and you might be able to fix that with config changes. If you share more we can make more specific recommendations.
Josh