Hello,
if you want to merge so many LAS 1.0/1.1/1.2/1.3 files whose total number of points exceeds 2^32-1 = 4,294,967,295 then you need to upgrade the format to LAS 1.4 as follows:
las2las -i many\*.laz -merged -set_version 1.4 -o merged14.laz
If you want to *quickly* check the total number of points in the set of LAS/LAZ file you want to merge into one file you should run:
lasinfo -i many\*.laz -merged -no_check
There should not be a limit on the number of files. That said - in general I advise people against merging too many LiDAR points into too large files. I consider this bad practice. For LAStools (and many other LiDAR softwares) can always "merge on-the-fly" using the '-i many\*.laz -merged' option. In my experience using reasonably sized tiles is a more practical way to manage large amounts of LiDAR.
Regards,
Martin @rapidlasso