Hi Jennifer,
Islandora Find & Replace offers a graphical user interface for finding a set of datastreams, and a useful web form for defining the 'find' string and the 'replace with' string. It then lets you performs the find and replace operation on the datastreams. It only works on text-based datastreams like XML files or OCR. It's much more friendly to more users than Datastream CRUD but it by design only does one (extremely useful) thing - search and replace text strings.
Islandora Datastream CRUD offers only a set of drush commands. It doesn't do the actual modification of datastream content, it just provides command-line tools for retrieving the datastream content, saving it as files, and then pushing the (modified by some other process or software) new versions of the datastream content files back up to your repository. It doesn't care whether the datastreams are text, image, video, etc. because it just retrieves and pushes files. It can also delete datastreams from your repository. It's not as user friendly as Find & Replace but it's more of tool that will let you do whatever you want to your datastreams, provided you have some additional tool to perform the actual modification of the datastreams.
They're both tools that help you manage datastreams, but they have different functionality and intended users. One thing they do have in common is that if used without a lot of testing and caution, can do extensive damage to your datastreams that would be difficult to fix if the damage affected a lot of objects.
Mitch may want to weigh in,
Mark