No. Instances don't get reloaded per request with Endpoints. That would be a terrible waste of resources.
Sorry, I probably should have clarified/explained more in my previous email, but I was in a bit of a rush when I wrote that. Endpoints doesn't support static methods (
see this article, scroll down to the API Methods header ) unless they're marked as private. When OP tried to run his static method, it may not have run or failed off.
In addition, I cheated a little bit on the answer and noted that the OP cross-posted
his question to SO, where he said that he needed data tables precomputed during init. That's something that really needs to be moved to a regular cron or similar.
@OP/Mike: Can you post a simple test case?