...lack of knowledge on node, webpack, and how javascript frameworks come together to make a basic web app...
Prior to coming to work here on Eve, my day job for two years was building and maintaining a NodeJS stack. Having used browserify, webpack, and systemJS, I've come to accept that packaging for the web is just really complicated. I imagine many other users (including JS experts) will struggle with the same thing. We put together the starter as one example, but I think the best thing we can do to help the community here is to have champions of various tooling stacks step forward and make their own starters (e.g. for webpack and babel) like we have for SystemJS and TypeScript. Concrete examples coupled with experiential documentation written by people with the same goal as you is the best way I know of to make Lovecraftian first steps like this more approachable.
On our side, we can at least insulate users who are building their project in Eve from the ground up from most of this difficulty by managing the packaging for them. Once we've finished the 0.3 editor experience we can start to do more of that tooling goodness again. :)