Protein Folding

[Dan Wood]

Is there any possible way to study protein folding at home aside from the popular Fold.it game?

[Bryan Jones]

Definitely. There is lots of software available, some free, some expensive. What are you looking to do regarding protein folding?

On Wed, Feb 14, 2018, 7:40 AM Dan Wood <danw...@gmail.com> wrote:

Is there any possible way to study protein folding at home aside from the popular Fold.it game?

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[John Ladasky]

On Wednesday, February 14, 2018 at 5:40:55 AM UTC-8, Dan Wood wrote:

Is there any possible way to study protein folding at home aside from the popular Fold.it game? 

GROMACS is a free and open-source molecular dynamics package.  It has a steep learning curve though!

 http://www.gromacs.org/

[Bryan Jones]

Molecular dynamics software like GROMACS is useful for studying protein movements and maybe the folding process. A more approachable way to start is by looking at/analyzing existing protein folds. PyMol is my favorite protein visualization software. There is a paid version, free educational version (if you have a .edu email), and free open-source compilable code. You can download protein structure files to look at from the Protein Data Bank. If you want to predict unknown structures, a great tool is homology modeling (e.g. Swiss Model). If you want to go deep down the rabbit hole of protein modeling, Rosetta is probably the most powerful tool. It is what powers Fold.it (and maybe folding@home, I don't remember). 

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[Cory J. Geesaman]

What's your knowledge level of programming and protein structure currently?

[Michael Flynn]

If you have an academic email address you can try Rosetta:

https://www.rosettacommons.org/software/license-and-download

On Wednesday, February 14, 2018 at 5:40:55 AM UTC-8, Dan Wood wrote:

[xuwen wenxu]

Not Protein folding...But DNA which i personally think is much easier to fold :)
, could try OXDNA ,i just started playing with it,  its not that hard and quite fun to play around with

Cheers