Mike,
This is definitely outside my area of expertise but I suspect the thrombosis is a result of some other protein associated with the AstraZeneca vaccine, which is an adenovirus edited with the SARS-CoV2 spike protein gene ( ChAdOx1 NCoV-19), while the Moderna and Pfizer-BioNtech vaccines contain a much simpler genetic construct containing only part of the mRNA transcribed from the SARS-CoV2 spike protein gene.
This article describes the other transcription activity, aside from the SARS-CoV2 spike protein, associated with the AstraZeneca vaccine:
From what I’ve read briefly, the rest of the ingredients in the AstraZeneca vaccine have been used in prior vaccines. The adenovirus used is a new thing, so I suspect that is the culprit.
My take away is that mRNA vaccines will be the vaccines of the future if their immune boost lasts as well as prior vaccines. People can make them really fast, run huge amounts of trials, and lab technicians will not handle live virus except for those doing the initial harvesting and sequencing. I imagine it’ll be a lot cheaper, too.
Matt