Biomarkers - RE: [DIYbio] Re: Looking for partner or group for DIY TPE
Johnny Adams GRG Exec Director
Frank's list of markers below seem practical and make a lot of sense (blood pressure, exercise capacity . . .). I'd be interested in knowing how exercise capacity is measured.
Large biomarker sets can get complicated. And it's the end results like mobility, maintaining cognitive ability, enjoyment of life etc we seek.
DNA methylation is perhaps the most valuable marker, but I usually use multiple measures and look for shifts toward youth in all, or at least most, of them.
For your consideration here’s one sample set you can adapt to your own purpose
See Part 3 - page 36 here
https://www.aginginterventionfoundation.org/AgingInterventionProgram.pdf
where it says:
Here’s ONE EXAMPLE -- used for our recent small study.
This set can be adapted for many other therapies.
Basic Biomarker Set/Protocol
Biomarker/objective measure plan for our recent small study
Johnny
John M. “Johnny” Adams
Executive Director Gerontology Research Group
JAd...@grg.org (949) 922-9786 cell
~~~~
CEO / Exec. Director Aging Intervention Foundation / Bourhenne Medical Research Foundation
https://www.aginginterventionfoundation.org/AgingInterventionProgram.pdf
http://www.AgingIntervention.org
http://www.AgingIntervention.org/JohnnyAdamsBackgroundSummary.htm
From: diy...@googlegroups.com <diy...@googlegroups.com> On Behalf Of Frank Garcia
Sent: Tuesday, June 30, 2020 12:05 PM
To: DIYbio <diy...@googlegroups.com>
Subject: Re: [DIYbio] Re: Looking for partner or group for DIY TPE
As far as whether proprietary tests of epigenetic changes are the way to go I think that for measuring whether "rejuvenation" has occurred we don't need to spend a bunch of money or get too fancy. Just look in the mirror, so to speak. If I am being rejuvenated then that's going to be reflected in my blood pressure, exercise capacity, sleep patterns, LDL, bone density, GFR, etc. So the standard diagnostic lab tests will reflect those changes.
On Tuesday, June 30, 2020 at 2:56:56 PM UTC-4 Frank Garcia wrote:
I guess we need to define rejuvenation then. the biomarker tests in the experiment each measures one tiny piece of the physiological state which, depending on the direction in which the marker changed, indicates a physiological state that more closely resembles that of a younger organism. I'm not sure (maybe i'm wrong) there is a universally accepted definition of rejuvenation. and there certainly isn't any single market that proves rejuvenation. It's simply too complex for that to ever be the case. It's more like pick your basket of markers of aging and test them over a period of time and see which way they are heading. I personally think any markers of rejuvenation has to include those that measure the physiological dirvers of age -related disease and deterioration such as insulin sensitivity, fibrotic markers, resting heart rate, muscle stem cells, mitochondrial markers, cholesterol trajectory, cardiac output efficiency, C-reactive protein, just to name a few out of a million. In the study, muscle anabolism vs catabolism is in fact a good aging biomarker
On Tuesday, June 30, 2020 at 2:20:11 AM UTC-4 Raph N wrote:
The problem with the biomarkers used in the experiment is that they can't prove rejuvenation. For example we know exercise improve lots of biomarkers, yet it does not rejuvenate you, or you could exercise your way to immortality.
As far as we know epigenetic clock is the best marker of biological age.
Raphael <rap...@gmail.com>
On Tue, Jun 30, 2020, 01:50 Frank Garcia <fgarc...@gmail.com> wrote:
I don't know too much about the epigenetic tests however it might be useful for you to take a look at the biomarker tests that were used in the experiment that I posted which started this discussion. They did pretty rigorous testing of multiple systems and tissues to determine efficacy.
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