Are you sure? Depending on what permissions the usb port has, you may need to use sudo to run lsof:
sudo lsof /dev/ttyUSB0
Come to think of it, you may have to do that with minicom, too.
Personally, I change the udev rule that governs permissions for usb devices to give everyone access to the port. The rule that governs this is most likely in the directory /lib/udev/rules.d, but which file it is in depends on the operating system. I believe on Raspbian, it's in file 91-permissions.rules, but it may be in 50-udev-default.rules. Wherever you find it, you want to change this
SUBSYSTEM=="usb", ENV{DEVTYPE}=="usb_device", MODE="0664"
to this
SUBSYSTEM=="usb", ENV{DEVTYPE}=="usb_device", MODE="0666"
-tk