Short answer is you will need to run two instances of WeeWX, either on a single device or separate devices. I am in much the same boat having run the vantage driver for many years and recently bought a GW1000 and a number of temp/hum sensors and soil moisture sensors. A given WeeWX instance can only run one driver so hence the need for separate WeeWX instances. You can have a WeeWX service that can obtain observational data and add it to loop packets/archive records emitted by the driver, some drivers can run as a driver or a service but the vantage and interceptor drivers cannot.
To run separate WeeWX instances you will need separate config files and databases for each. Reporting is up to you but if you intend combining data from both devices it may be easiest to have one instance handle the reporting, though if you intend having separate reports then each instance will require its own reporting. The wiki has a fairly good article on setting it up (https://github.com/weewx/weewx/wiki/weewx-multi).
I have found the biggest challenge was remembering I have two WeeWX instances running and the need to use specific service names when controlling the individual services/instances (after being used to just using systemctl xxxxxx weewx that now affects both services). Getting your logs sorted is also important, log entries for each instance will be identified separately but I found it easier to send each to separate log files, This is covered at the bottom of the Put log messages from WeeWX in a separate file article in the wiki (https://github.com/weewx/weewx/wiki/logging).
Both running fine now under WeeWX 4.1.0/python 3.
Gary