Hi Philip,
Unfortunately a bug was introduced in Safari's validation for WEBGL_multi_draw along with what looks like a security bug fix.
Sorry that a regression like this made it past automated testing of any browser. There are safeguards in place to prevent this sort of thing from happening, but it looks like there are some gaps in WebGL conformance testing in WebKit.
In the interim - I'd encourage you and other developers to test your products regularly with pre-release versions of browsers like Chrome Canary / Dev, Firefox Nightly, Microsoft Edge Canary Channel, and Safari Technology Preview, and file any bugs against browsers as soon as you see them.
Thanks,
-Ken