Yes, there is a configuration. The issue here is that
owl:differentFrom is only declared to be owl:SymmetricProperty in
the RDF/OWL system triples, and those are not included in the
inferences by default. You can include those into the inferencing
process if you go to Inference > Configure Inferencing and then
add the RDF/OWL system triples as shown. You will then see various
additional inferences.

Alternatively, add the owl:differentFrom rdf:type owl:SymmetricProperty triple into your ontologies.
HTH
Holger
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