To manage large collections of images, I recommend having them in a folder next to your wiki. Well, the actual setup depends on how you are hosting/serving your wiki.
If you open a local `index.html` or equivalent, with one of the browser savers, then you can simply have an `./images` directory next to your wiki, and then you will need to create a tiddler for each image with the `type` field set correctly, and the `_canonical_url` field set to either the local path "./images/monaLisa_daVinciLeonardo.png", or the absolute path "/c/tiddlywikis/artwiki/images/monaLisa_daVinciLeonardo.png". Then you can call it in other places with its title like `[img[Leonardo DaVinci/Mona Lisa]]` or `{{Leonardo DaVinci/Mona Lisa}}`.
If you are serving the wiki from Node.js, there is a way to define the metadata for all files ina folder, and import them all in one go.
Ref:
https://tiddlywiki.com/#Using%20the%20integrated%20static%20file%20server:%5B%5BImages%20in%20WikiText%5D%5D%20ExternalImages%20%5B%5BUsing%20the%20integrated%20static%20file%20server%5D%5D