Hi there,
I've been doing just this for the past year. TW is a wonderful tool for the purpose, but it does need some tweaking in order to be usable as live notetaking.
Here are some tips:
* Use the node version of TW. Preferably storing it on dropbox or some cloud provider so you don't want to kill yourself the day your HDD fails and you loose 3 months of work (been there)
* You need the KaTeX plugin for typesetting math equations
* Get a powerful keyboard-macro program (on macOS I am using
https://www.keyboardmaestro.com/main/, most well-spent 30$ of the year) and define keyboard shortcuts for common latex symbols and structures. That is your only hope of entering math equations fast enough. Chorded shortcuts (that involve more than one combination of keys) are especially helpful to organize shortcuts in an easy to remember way.
For instance, `cmd-l + l` writes the KaTeX delimiters and positions the cursor between them:
`cmd-l + k` starts listening for greek symbols input: whatever character I press next is converted to the corresponding greek symbol in latex. Ex:
t -> \theta
T (shift-t) -> \Theta
w -> \omega
d -> \delta
D (shift-t) -> \Delta
alt-d -> \partial (delta used in partial derivatives)
etc.
`cmd-l + w` starts listening for triggers for "wrapping" latex expressions, and positions the cursor at the right spot:
i -> \int_{}^{} , positions the cursor inside the first set of brackets
s -> \sin\left( \right), positions the cursor after the "("
a -> \begin{aligned} \end{aligned} , for blocks of several equations
There's a lot more, those are just some examples. This allows me to write latex equations/notes extremely fast, and is the only way I found to keep up the pace of a lecture.
* Write a script or find some way to speedup the image import process. That's something I complained about several times before here, inserting images is sooo clunky in TW and completely disrupts the notetaking flow.
With a combination of the keyboard shortcut program above and some bash scripting, I now have a keyboard shortcut that allows me to capture a screenshot of the area I need, save it in the TW folder with a random name, generate the corresponding .meta tiddly file, and put the corresponding `[img[img_name]]` in my clipboard so that I can paste it inside my tiddly. It now takes me less than a second to insert images in my notes.
* Define some tiddlywiki macros for stuff like "definition", "example", "important", etc. an associate them to keyboard shortcuts so you can take structured notes without losing too much time for it.
* Find the right level of "graining" for your tiddly's. I initially split my notes into very, very small chunks (tiddlys) but I found that to be counter-productive. My heuristic is now "will I ever need to link to this concept on its own ?" . If yes, it goes into a tiddly. Otherwise, just include inside the "parent" tiddly.
That's what comes to mind now.
If you work on macOS, feel free to message me, I will be happy to send you the macros/scripts that I have.